The relationship between obstructive sleep apnea and intra-epidermal nerve fiber density, PARP activation and foot ulceration in patients with type 2 diabetes
| Autor: | Asad Ali, Abd A. Tahrani, Milan K. Piya, Neil T. Raymond, Quratul-ain Altaf |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Michigan medicine.medical_specialty Endocrinology Diabetes and Metabolism Poly (ADP-Ribose) Polymerase-1 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology 03 medical and health sciences Nerve Fibers 0302 clinical medicine Endocrinology stomatognathic system Internal medicine Diabetes mellitus Internal Medicine medicine Humans Endothelial dysfunction Aged Sleep Apnea Obstructive business.industry Sleep apnea Middle Aged medicine.disease Diabetic foot Diabetic Foot nervous system diseases respiratory tract diseases Obstructive sleep apnea Cross-Sectional Studies Peripheral neuropathy Diabetes Mellitus Type 2 Apnea–hypopnea index Female Epidermis business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Diabetes and its Complications. 30:1315-1320 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2016.05.025 |
| Popis: | BACKGROUND Obstructive sleep apnea (OSA) is associated with increased nitrosative stress, endothelial dysfunction, and peripheral neuropathy in patients with type 2 diabetes. We hypothesized that OSA is associated with Poly ADP ribose polymerase (PARP) activation, lower intra-epidermal nerve fiber density (IENFD), and diabetic foot ulceration (DFU). METHODS A cross-sectional study of adults with type 2 diabetes recruited from a secondary care hospital in the UK. OSA was assessed by multi-channel home-based cardio-respiratory device (Alice PDX, Philips Respironics). DPN was assessed using the Michigan Neuropathy Screening Instrument (MNSI). IENFD and % PAR stained nuclei were assessed using immunohistochemistry staining on skin biopsies. DFU was assessed based on MNSI. RESULTS Skin biopsies and DFU data were available from 52 and 234 patients respectively. OSA was associated with lower IENFD (12.75±1.93 vs. 10.55±1.62 vs. 9.42±1.16 fibers/mm of epidermis for no OSA, mild OSA and moderate to severe OSA respectively, p |
| Databáze: | OpenAIRE |
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