White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study
| Autor: | Murray B. Stein, Michael J. Coleman, Ross Zafonte, Amicie de Pierrefeu, Gerald A. Grant, Sylvain Bouix, Christian Lepage, Norberto Andaluz, Inga K. Koerte, Lori Shutter, Thomas W. McAllister, Rajendra A. Morey, Martha E. Shenton, Raul Coimbra, Laura A. Flashman, Christine E. Marx, Ofer Pasternak, Mark S. George |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Traumatic brain injury Cognitive Neuroscience Poison control Comorbidity behavioral disciplines and activities Article 050105 experimental psychology Stress Disorders Post-Traumatic White matter 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine Neuroimaging Internal medicine mental disorders Fractional anisotropy medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Psychiatry Brain Concussion Depression (differential diagnoses) 05 social sciences Traumatic stress Brain medicine.disease White Matter Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Neurology Cardiology Female Neurology (clinical) Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Brain Imaging and Behavior. 12:870-881 |
| ISSN: | 1931-7565 1931-7557 |
| DOI: | 10.1007/s11682-017-9744-5 |
| Popis: | Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries. Using a subject-specific approach, we compared fractional anisotropy (FA) abnormalities between groups with a history of mTBI (n = 35), comorbid mTBI and PTSD (mTBI + PTSD; n = 22), and healthy controls (n = 37). We compared all three groups on the number of abnormal FA clusters derived from subject-specific injury profiles (i.e., individual z-score maps) along a common white matter skeleton. The mTBI + PTSD group evinced a greater number of abnormally low FA clusters relative to both the healthy controls and the mTBI group without PTSD (p |
| Databáze: | OpenAIRE |
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