Arterial injury repair in nonhuman primates-the role of PDGF receptor-beta
| Autor: | Suzanne Hawkins, Richard D. Kenagy, Günter Daum, Michael J Englesbe, Patrick C.H. Hsieh, Alexander W. Clowes, Mark G. Davies |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Platelet-derived growth factor Intimal hyperplasia Antibodies Catheterization Receptor Platelet-Derived Growth Factor beta chemistry.chemical_compound biology.animal medicine Animals Leg Wound Healing biology business.industry Arteries Hyperplasia medicine.disease Blockade medicine.anatomical_structure chemistry biology.protein Wounds and Injuries Surgery business Tunica Intima Tunica Media Platelet-derived growth factor receptor Cell Division Baboon Blood vessel Artery Papio |
| Zdroj: | The Journal of surgical research. 119(1) |
| ISSN: | 0022-4804 |
| Popis: | Background This study documents the time course of the response to injury of the saphenous artery in baboons and the role of the platelet-derived growth factor-β. Fundamental differences with the well-characterized rat arterial injury model have been found. Materials and methods Thirty-eight baboons received a unilateral balloon injury to the saphenous artery and were treated with a chimeric blocking antibody to PDGFR-β or vehicle control for 7, 14, or 28 days. The arteries were evaluated morphologically and for cell proliferation. Results Both medial and intimal smooth muscle cell proliferation were elevated 7 days after injury and were back close to baseline at 14 days. Unlike the rat, blockade of PDGFR-β inhibited medial proliferation over 80% at 7 and 14 days, while intimal proliferation was only inhibited at 14 days (>95%). Also, unlike the rat, the baboon arterial media, as well as the intima, increased in size by 14 days after injury. Blockade of PDGFR-β completely inhibited both intimal and medial growth at 14 days, but there was less of an effect on intimal growth at 28 days. Conclusion Blockade of PDGFR-β may be a clinical approach to inhibit intimal hyperplasia in humans, but this study raises concerns about the long-term efficacy of this treatment. |
| Databáze: | OpenAIRE |
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