Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
| Autor: | Santana A. L. Thomas, Jacqueline L. von Salm, Steve Ferlita, Christopher A. Rice, Nerida G. Wilson, Ala Azhari, Dennis E. Kyle, Prasanth Nemani, Bill J. Baker, Shane Clark |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Macrocyclic Compounds Stereochemistry Plumarella Coral Antarctic Regions Pharmaceutical Science Crystallography X-Ray 01 natural sciences Deep sea Article Mass Spectrometry Analytical Chemistry Terpene 03 medical and health sciences chemistry.chemical_compound Anthozoa Drug Discovery Animals Nuclear Magnetic Resonance Biomolecular Plumarella delicatissima Pharmacology biology 010405 organic chemistry Chemistry Organic Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification 0104 chemical sciences 030104 developmental biology Complementary and alternative medicine Molecular Medicine Diterpenes Diterpene Leishmania donovani |
| Zdroj: | Journal of Natural Products |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.7b00732 |
| Popis: | During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography. |
| Databáze: | OpenAIRE |
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