Lower expression of endogenous intestinal alkaline phosphatase may predict worse prognosis in patients with Crohn’s disease
| Autor: | Su-Mi Lee, Sung-Kyu Choi, Jong-Sun Rew, Sunmin Kim, Ji-Ho Seo, Ji Young Kim, Seon-Young Park, Young-Eun Joo, Chang-Hwan Park, Hyun-Chul Kim, Jae-Kyun Ju, Dong Hyun Kim, Jin Ook Chung, Jae Hyuk Lee |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Crohn’s disease medicine.medical_specialty Adolescent Colon Gene Expression Inflammation Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Crohn Disease Intestinal mucosa Recurrence Internal medicine Biopsy medicine Humans RNA Messenger Intestinal Mucosa lcsh:RC799-869 Young adult Crohn's disease medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry General Medicine Middle Aged Hepatology Alkaline Phosphatase Prognosis medicine.disease Receptors Interleukin-6 Toll-Like Receptor 4 030220 oncology & carcinogenesis Alkaline phosphatase Female lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Tumor necrosis factor alpha medicine.symptom business Research Article |
| Zdroj: | BMC Gastroenterology, Vol 18, Iss 1, Pp 1-6 (2018) BMC Gastroenterology |
| ISSN: | 1471-230X |
| DOI: | 10.1186/s12876-018-0904-x |
| Popis: | Backgrounds Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous IAP in patients with Crohn’s disease (CD). Methods A total of 32 consecutive patients (14 males) with CD were included in the study. We measured the level of endogenous iAP in inflamed and noninflamed colonic mucosa. To verify the inflammation status, we measured the level of mRNA for IL-6, TNF-α, and TLR-4. We monitored the clinical courses of patients during follow-up after acquisition of biopsy specimens. Results Median age of patients was 22.5 years (range, 15–49). Median CD activity index (CDAI, range) was 93.7 (22.8~ 154.9). There were colonic involvements in all patients and perianal involvement in 43.8% patients. The mRNA levels of IL-6 (p = 0.005) and TLR-4 (p = 0.013) in inflamed mucosa were significantly higher than those in non-inflamed mucosa. However, there was no difference of expression of TNF-α mRNA (p = 0.345). During a 14-month follow-up (range, 9 months–54 months), there were 19 patients with clinical recurrences. There were 9 patients (9/19, 47.4%) with IAP expression ratio (inflamed to non-inflamed) ≤ 1.0 in patients with clinical recurrence while there was one patient (1/13, 7.7%) with IAP ratio ≤ 1.0 in patients without clinical recurrence (p = 0.024). Conclusion Lower expression of IAP in inflamed mucosa compared to non-inflamed mucosa may be associated with clinical recurrence in patients with CD. |
| Databáze: | OpenAIRE |
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