EXPRESSION OF REG1Α, GAST AND TGFB1 GENES IN CONDITIONS OF STRESSINDUCED GASTRIC MUCOUS LESIONS DEVELOPMENT AND HEALING IN RATS
| Autor: | O O Morgaienko, A. S. Dranitsina, Ostapchenko Li, D. M. Grebinyk |
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| Předmět: |
Male
medicine.medical_specialty Physiology medicine.disease_cause Lipid peroxidation Lesion Transforming Growth Factor beta1 chemistry.chemical_compound Immobilization Internal medicine Malondialdehyde Gene expression Gastrins Immersion Lithostathine medicine Gastric mucosa Animals Outbred Strains Animals Stomach Ulcer Gastrin Regulation of gene expression business.industry Stomach Water Recovery of Function Rats Oxidative Stress Endocrinology medicine.anatomical_structure chemistry Gene Expression Regulation Gastric Mucosa Lipid Peroxidation medicine.symptom business Oxidative stress Stress Psychological |
| Zdroj: | Scopus-Elsevier |
| Popis: | Analysis of Reg1a gene expression in rat gastric mucosa under development and healing of stress-induced lesions was carried out. Increased expression of Reg1a was observed after 1 hour of stressor impact - 2,1 times, and achieved the maximum level expression after 3 hours of stress exposure - 3,5 times, that occurred on the background of lipid peroxidation intensification and antioxidant system dysfunction. The sharp decrease in 1,6 and 2 times of Reg1a gene expression was shown in 12 and 24 hours respectively after termination of the stressor action. Analysis of Gast gene expression did not confirm that gastrin stimulated Reg1a expression in gastric mucosa under water immersion restraint stress. The positive correlation between Reg1a and Tgfb1 genes expression was determined in the dynamics of stress-induced gastric lesions’ development and healing, which may indicate the involvement of Tgfb1 to acceleration of lesion’s healing. |
| Databáze: | OpenAIRE |
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