Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive–compulsive disorder

Autor: Taro Mizobe, Hirofumi Tomiyama, Kiyotaka Nemoto, Suguru Hasuzawa, Akio Hiwatashi, Mayumi Tomita, Aikana Ohno, Sae Tsuruta, Osamu Togao, Kenta Kato, Keitaro Murayama, Tomohiro Nakao
Rok vydání: 2021
Předmět:
Male
Obsessive-Compulsive Disorder
computer.software_genre
inferior frontal gyrus
Thalamus
Voxel
cortico‐striato‐thalamo‐cortical circuit
Prefrontal cortex
Research Articles
Response inhibition
Cerebral Cortex
Radiological and Ultrasound Technology
medicine.diagnostic_test
cingulo‐opercular salience network
Motor Cortex
Middle Aged
Magnetic Resonance Imaging
Inhibition
Psychological
medicine.anatomical_structure
Neurology
Female
Anatomy
Research Article
Adult
Inferior frontal gyrus
stop‐signal task
Motor Activity
fronto‐striatal circuit
behavioral disciplines and activities
Young Adult
obsessive–compulsive disorder
mental disorders
Connectome
medicine
Humans
response inhibition
Radiology
Nuclear Medicine and imaging
presupplementary motor cortex
Anterior cingulate cortex
business.industry
Inferior parietal lobule
Corpus Striatum
ventral attention cortico‐striato‐thalamo‐cortical circuit
resting‐state functional MRI
Neurology (clinical)
Nerve Net
Functional magnetic resonance imaging
business
Neuroscience
Insula
computer
Zdroj: Human Brain Mapping
ISSN: 1097-0193
1065-9471
DOI: 10.1002/hbm.25699
Popis: Recent evidence suggests that presupplementary motor area (pre‐SMA) and inferior frontal gyrus (IFG) play an important role in response inhibition. However, no study has investigated the relationship between these brain networks at resting‐state and response inhibition in obsessive–compulsive disorder (OCD). We performed resting‐state functional magnetic resonance imaging scans and then measured the response inhibition of 41 medication‐free OCD patients and 49 healthy control (HC) participants by using the stop‐signal task outside the scanner. We explored the differences between OCD and HC groups in the functional connectivity of pre‐SMA and IFG associated with the ability of motor response inhibition. OCD patients showed a longer stop‐signal reaction time (SSRT). Compared to HC, OCD patients exhibit different associations between the ability of motor response inhibition and the functional connectivity between pre‐SMA and IFG, inferior parietal lobule, dorsal anterior cingulate cortex, insula, and anterior prefrontal cortex. Additional analysis to investigate the functional connectivity difference from the seed ROIs to the whole brain voxels revealed that, compared to HC, OCD exhibited greater functional connectivity between pre‐SMA and IFG. Also, this functional connectivity was positively correlated with the SSRT score. These results provide additional insight into the characteristics of the resting‐state functional connectivity of the regions belonging to the cortico‐striato‐thalamo‐cortical circuit and the cingulo‐opercular salience network, underlying the impaired motor response inhibition of OCD. In particular, we emphasize the importance of altered functional connectivity between pre‐SMA and IFG for the pathophysiology of motor response inhibition in OCD.
Obsessive–compulsive disorder patients had significantly different associations between the abilities of motor response inhibition and the resting‐state functional connectivity from pre‐SMA to IPL, IFG, dACC and anterior‐insula. Additionally, compared to healthy control, OCD exhibited greater functional connectivity between pre‐SMA and IFG, and this functional connectivity was correlated with the the abilities of motor response inhibition.
Databáze: OpenAIRE
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