Early-Life Adversity Leaves Its Imprint on the Oral Microbiome for More Than 20 Years and Is Associated with Long-Term Immune Changes
| Autor: | Pauline Guebels, Johannes Hertel, Claude P. Muller, Martha M.C. Elwenspoek, Sophie B. Mériaux, Eleftheria G. Charalambous, Jonathan D. Turner, Fleur A. D. Leenen, Ines Thiele |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
microbiome early-life adversity medicine.disease_cause bacterial community host-microbe interactions Cohort Studies 0302 clinical medicine Adverse Childhood Experiences Biology (General) Child Spectroscopy media_common 0303 health sciences Microbiota General Medicine Immunosenescence Computer Science Applications Chemistry oral microbiome Female Psychological resilience Oral Microbiome Senescence Adult early experience developmental origins of health and disease immune system QH301-705.5 media_common.quotation_subject Context (language use) Biology Catalysis Herpesviridae Article Inorganic Chemistry Life Change Events 03 medical and health sciences Young Adult Immune system medicine Humans Microbiome Physical and Theoretical Chemistry Saliva Molecular Biology QD1-999 030304 developmental biology Bacteria Organic Chemistry Mouth Mucosa Case-Control Studies Immunology 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 12682, p 12682 (2021) International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12682 |
| ISSN: | 1422-0067 |
| Popis: | The early-life microbiome (ELM) interacts with the psychosocial environment, in particular during early-life adversity (ELA), defining life-long health trajectories. The ELM also plays a significant role in the maturation of the immune system. We hypothesised that, in this context, the resilience of the oral microbiomes, despite being composed of diverse and distinct communities, allows them to retain an imprint of the early environment. Using 16S amplicon sequencing on the EpiPath cohort, we demonstrate that ELA leaves an imprint on both the salivary and buccal oral microbiome 24 years after exposure to adversity. Furthermore, the changes in both communities were associated with increased activation, maturation, and senescence of both innate and adaptive immune cells, although the interaction was partly dependent on prior herpesviridae exposure and current smoking. Our data suggest the presence of multiple links between ELA, Immunosenescence, and cytotoxicity that occur through long-term changes in the microbiome. |
| Databáze: | OpenAIRE |
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