A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
| Autor: | J Kerry-Smith, Duolao Wang, Mark Andrew Good, Benjamin H. Mullish, Timothy R. Hughes, Zuzana Paduchova, J F Plummer, K E Loxley, Jana Muchová, Daryn Robert Michael, T. S. Davies, Giulia Masetti, Iveta Garaiova, Sue Plummer, Julian R. Marchesi, A A Jack, Julie A. K. McDonald |
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| Přispěvatelé: | Imperial College Healthcare NHS Trust- BRC Funding |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Waist Normal diet lcsh:Medicine Overweight Rate ratio Placebo Article 03 medical and health sciences qu_145.5 Double-Blind Method Quality of life Nutritional supplements Weight loss Internal medicine Weight Loss medicine Humans Obesity lcsh:Science wd_200 Respiratory Tract Infections wd_100 Nutrition Randomized Controlled Trials as Topic 030109 nutrition & dietetics Multidisciplinary business.industry Probiotics Incidence (epidemiology) lcsh:R Body Weight Lactobacillus 030104 developmental biology Quality of Life lcsh:Q Female Bifidobacterium Waist Circumference medicine.symptom business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
| ISSN: | 2045-2322 |
| Popis: | In an exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study (ISRCTN12562026, funded by Cultech Ltd), 220 Bulgarian participants (30 to 65 years old) with BMI 25–34.9 kg/m2 received Lab4P probiotic (50 billion/day) or a matched placebo for 6 months. Participants maintained their normal diet and lifestyle. Primary outcomes were changes in body weight, BMI, waist circumference (WC), waist-to-height ratio (WtHR), blood pressure and plasma lipids. Secondary outcomes were changes in plasma C-reactive protein (CRP), the diversity of the faecal microbiota, quality of life (QoL) assessments and the incidence of upper respiratory tract infection (URTI). Significant between group decreases in body weight (1.3 kg, p 2, p p p p p = 0.0005). Greatest weight losses were among probiotic hypercholesterolaemic participants (−2.5%, p p = 0.0241). Improvements in QoL and the incidence rate ratio of URTI (0.60, p |
| Databáze: | OpenAIRE |
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