Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease
| Autor: | Yasuhito Tanaka, Kentaro Matsuura, Saiyu Tanaka, Yoshito Itoh, Kohichiroh Yasui, Kanji Yamaguchi, Masashi Takemura, Yuya Seko, Naomi Mochizuki, Atsushi Umemura, Tasuku Hara, Taichiro Nishikawa, Keiichiro Okuda, Michihisa Moriguchi, Hiroyoshi Taketani, Kenichi Nishioji, Masao Kobayashi, Mai Kamaguchi, Kojiroh Mori, Naoki Mizuno |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male 0301 basic medicine medicine.medical_specialty Adolescent Genotype Tolloid-Like Metalloproteinases Polymorphism Single Nucleotide Gastroenterology Statistics Nonparametric Body Mass Index Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Japan Non-alcoholic Fatty Liver Disease Fibrosis Internal medicine Nonalcoholic fatty liver disease Prevalence medicine Humans Aspartate Aminotransferases Serum Albumin Aged Aged 80 and over Hepatitis business.industry Membrane Proteins Lipase Odds ratio Middle Aged Hepatology medicine.disease 030104 developmental biology Multivariate Analysis Cohort Female 030211 gastroenterology & hepatology Hepatic fibrosis business Body mass index |
| Zdroj: | Journal of Gastroenterology. 53:438-448 |
| ISSN: | 1435-5922 0944-1174 |
| Popis: | Hepatic fibrosis is an independent risk factor for mortality and liver-related events in patients with nonalcoholic fatty liver disease (NAFLD). PNPLA3 rs738409 has been associated with fibrosis in viral and non-viral hepatitis. TLL1 rs17047200 also has been associated with developing hepatocellular carcinoma probably via hepatic fibrogenesis. We estimated the impact of these genetic polymorphisms on hepatic fibrosis in Japanese patients with NAFLD. We analyzed the association between these genetic variants and the backgrounds of 817 individuals who received health checkups (health check cohort) from 2012 to 2014. Then, we investigated the relationship between genetic variants and liver histology in 258 consecutive patients with biopsy-proven NAFLD in Japan (NAFLD cohort) from 2012 to 2017 (UMIN000027399). The prevalence of PNPLA3 CG/GG in the NAFLD cohort was higher than that in the health check cohort (p |
| Databáze: | OpenAIRE |
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