Antigen 5 allergens of hymenoptera venoms and their role in diagnosis and therapy of venom allergy
| Autor: | Murilo Luiz Bazon, Maria Beatrice Bilò, Carsten B. Schmidt-Weber, Johannes Grosch, Thilo Jakob, Márcia Regina Brochetto-Braga, Simon Blank |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Component-resolved diagnostics Allergy Immunology Polistes dominula venom Wasp Venoms Venom Hymenoptera Antigen 5 Component-resolved Diagnostics Allergen Cross-reactivity Hymenoptera Venom Allergy Polistes Dominula Venom Yellow Jacket Venom 03 medical and health sciences 0302 clinical medicine Antigen Hypersensitivity Animals Humans Immunology and Allergy Medicine Arthropod Venoms Sensitization biology Allergen cross-reactivity business.industry SUPERFAMILY Yellow jacket venom biology.organism_classification medicine.disease Vespoidea ddc 030104 developmental biology medicine.anatomical_structure Superfamily vespoidea 030228 respiratory system Allergens (RK Bush and S Vieths Section Editors) Hymenoptera venom allergy business |
| Zdroj: | Curr. Allergy Asthma Rep. 20:58 (2020) Current Allergy and Asthma Reports |
| Popis: | Purpose of Review Stings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions. Recent Findings Antigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed. Summary Antigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species. |
| Databáze: | OpenAIRE |
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