Restriction spectrum imaging improves MRI-based prostate cancer detection
| Autor: | Kevin C. McCammack, Steven S. Raman, Shaun R. Best, Daniel Margolis, Rahul S. Desikan, Nathan S. White, Christopher J. Kane, Jared Heimbigner, Anders M. Dale, Robert M. Marks, Natalie M. Schenker-Ahmed, J. Kellogg Parsons, Joshua M. Kuperman, Hauke Bartsch, David S. Karow, Rebecca Rakow-Penner, Ahmed Shabaik, Michael A. Liss |
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| Rok vydání: | 2016 |
| Předmět: |
Diffuse weighted imaging
Male Pathology medicine.medical_specialty Biopsy Urology medicine.medical_treatment Prostate diffusion imaging Prostate MRI Contrast Media Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences Prostate cancer 0302 clinical medicine law Prostate 80 and over medicine Humans Radiology Nuclear Medicine and imaging Sextant Aged Aged 80 and over Prostatectomy Radiological and Ultrasound Technology medicine.diagnostic_test Receiver operating characteristic business.industry Gastroenterology Area under the curve Prostatic Neoplasms Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Tumor Burden medicine.anatomical_structure Restriction spectrum imaging 030220 oncology & carcinogenesis Neoplasm Grading Nuclear medicine business |
| Zdroj: | Abdominal radiology (New York), vol 41, iss 5 McCammack, KC; Schenker-Ahmed, NM; White, NS; Best, SR; Marks, RM; Heimbigner, J; et al.(2016). Restriction spectrum imaging improves MRI-based prostate cancer detection. ABDOMINAL RADIOLOGY, 41(5), 946-953. doi: 10.1007/s00261-016-0659-1. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2ts010xf |
| ISSN: | 2366-0058 2366-004X |
| DOI: | 10.1007/s00261-016-0659-1 |
| Popis: | PurposeTo compare the diagnostic performance of restriction spectrum imaging (RSI), with that of conventional multi-parametric (MP) magnetic resonance imaging (MRI) for prostate cancer (PCa) detection in a blinded reader-based format.MethodsThree readers independently evaluated 100 patients (67 with proven PCa) who underwent MP-MRI and RSI within 6months of systematic biopsy (N=67; 23 with targeting performed) or prostatectomy (N=33). Imaging was performed at 3Tesla using a phased-array coil. Readers used a five-point scale estimating the likelihood of PCa present in each prostate sextant. Evaluation was performed in two separate sessions, first using conventional MP-MRI alone then immediately with MP-MRI and RSI in the same session. Fourweeks later, another scoring session used RSI and T2-weighted imaging (T2WI) without conventional diffusion-weighted or dynamic contrast-enhanced imaging. Reader interpretations were then compared to prostatectomy data or biopsy results. Receiver operating characteristic curves were performed, with area under the curve (AUC) used to compare across groups.ResultsMP-MRI with RSI achieved higher AUCs compared to MP-MRI alone for identifying high-grade (Gleason score greater than or equal to 4+3=7) PCa (0.78 vs. 0.70 at the sextant level; P |
| Databáze: | OpenAIRE |
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