Effects of sodium bicarbonate dentifrices on the levels of cariogenic bacteria in human saliva
| Autor: | K. Legier-Vargas, S.A. Mundorff-Shrestha, John D. B. Featherstone, L.M. Gwinner |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Saliva Bicarbonate Colony Count Microbial Dentistry Dental Caries Placebo Placebos Streptococcus mutans chemistry.chemical_compound Fluorides Double-Blind Method In vivo Dentifrice Humans Food science General Dentistry Dentifrices Sodium bicarbonate Cross-Over Studies business.industry Chemistry Crossover study Lactobacillus Sodium Bicarbonate business Fluoride |
| Zdroj: | Caries research. 29(2) |
| ISSN: | 0008-6568 |
| Popis: | This investigation evaluated the efficacy of two bicarbonate-containing dentifrices (one with fluoride and one without) against one placebo dentifrice (containing neither fluoride nor bicarbonate) in vivo in a panel of human volunteers to determine whether or not sodium bicarbonate would affect salivary mutans streptococci and lactobacilli. Ten caries-inactive adults were divided randomly into three groups, each of which was exposed to all three dentifrices, in a crossover manner, during three 4-week test periods. Saliva samples were taken at 1-week intervals. Samples were stored on ice, and microbiological analyses were conducted. The statistical analyses showed that, over a 4-week period, there was a statistically significant (p < 0.05) reduction in numbers of mutans streptococci with the two bicarbonate dentifrices as compared with the placebo dentifrice. Although not statistically significant, a similar trend was observed with lactobacilli. Longer-term, large-scale studies need to be conducted to investigate the possible mechanisms of action of sodium bicarbonate on these organisms and to relate the results to possible cariostatic effects in humans. |
| Databáze: | OpenAIRE |
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