Transarterial radioembolization in patients with hepatocellular carcinoma of intermediate B2 substage
| Autor: | Iris Deppe, Caterina De Benedittis, Rita Golfieri, José Ignacio Bilbao, Alberta Cappelli, Macarena Rodríguez-Fraile, Bruno Sangro, Paloma Sangro, Eleonora Terzi, Cristina Mosconi, Jens Ricke |
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| Přispěvatelé: | Cappelli Alberta, Sangro, Paloma, Mosconi, Cristina, Deppe, Iri, Terzi, Eleonora, Bilbao, Jose I., Rodriguez-Fraile, Macarena, De Benedittis, Caterina, Ricke, Jen, Golfieri, Rita, Sangro, Bruno |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Radiology Nuclear Medicine and Imaging Carcinoma Hepatocellular Tare weight BCLC-B subclassification Hepatocellular carcinoma Transarterial radioembolization Transarterial Radioembolization Gastroenterology Transarterial chemoembolization 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Yttrium Radioisotopes Stage (cooking) Survival analysis Aged Neoplasm Staging business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Embolization Therapeutic Survival Analysis Clinical trial 030220 oncology & carcinogenesis Female Liver function Radiopharmaceuticals business Liver cancer |
| Popis: | Purpose: Patients with hepatocellular carcinoma (HCC) of intermediate stage (BCLC-B according to the Barcelona Clinic Liver Cancer classification) are a heterogeneous group with different degrees of liver function impairment and tumour burden. The recommended treatment is transarterial chemoembolization (TACE). However, patients in this group may be judged as poor candidates for TACE because the risk-benefit ratio is low. Such patients may receive transarterial radioembolization (TARE) only by entering a clinical trial. Experts have proposed that the stage could be further divided into four substages based on available evidence of treatment benefit. We report here, for the first time, the outcome in patients with BCLC-B2 substage HCC treated with TARE. Methods: A retrospective analysis of the survival of 126 patients with BCLC-B2 substage HCC treated with TARE in three European hospitals was performed. Results: Overall median survival in patients with BCLC-B2 substage was not significantly different in relation to tumour characteristics; 19.35 months (95% CI 8.27–30.42 months) in patients with a single large (>7 cm) HCC, and 18.43 months (95% CI 15.08–21.77 months) in patients with multinodular HCC (p = 0.27). However, there was a higher proportion of long-term survivors at 36 months among those with a single large tumour (29%) than among those with multiple tumours (16.8%). Conclusion: Given the poor efficacy of TACE in treating patients with BCLC-B2 substage HCC, TARE treatment could be a better choice, especially in those with a large tumour. |
| Databáze: | OpenAIRE |
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