Effects of ibuprofen treatment on the developing preterm baboon kidney
Autor: | Bradley A. Yoder, Steven R. Seidner, Ronald I. Clyman, Megan R. Sutherland, Lina Gubhaju, M. Jane Black, Donald C. McCurnin |
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Rok vydání: | 2012 |
Předmět: |
medicine.medical_specialty
Physiology Kidney Glomerulus Drinking Blood Pressure Ibuprofen Urine Biology Kidney Nephrotoxicity Pregnancy Internal medicine Ductus arteriosus biology.animal medicine Animals Drug Interactions Enzyme Inhibitors Ductus Arteriosus Patent omega-N-Methylarginine organic chemicals Anti-Inflammatory Agents Non-Steroidal Body Weight Articles Nephrons Organ Size medicine.disease medicine.anatomical_structure Endocrinology Animals Newborn Premature birth Premature Birth Omega-N-Methylarginine Female Nitric Oxide Synthase Papio medicine.drug Baboon |
Zdroj: | American Journal of Physiology-Renal Physiology. 302:F1286-F1292 |
ISSN: | 1522-1466 1931-857X |
Popis: | Preterm neonates are commonly exposed postnatally to pharmacological treatments for a patent ductus arteriosus. Exposure of the developing kidney to nephrotoxic medications may adversely impact renal development. This study aimed to determine the effect of early postnatal ibuprofen treatment, both alone and in combination with a nitric oxide synthase inhibitor (NOSi), on renal development and morphology. Baboon neonates were delivered prematurely at 125-day (125d) gestation (term = 185d) and were euthanized at birth or postnatal day 6. Neonates were divided into four groups: 125d gestational controls ( n = 8), Untreated ( n = 8), Ibuprofen ( n = 6), and ibuprofen (Ibu)+NOSi ( n = 4). Animals in the Ibuprofen and Ibu+NOSi groups received five doses of ibuprofen, with the Ibuprofen+NOSi animals additionally administered a NOS inhibitor ( NG-monomethyl-l-arginine). There was no difference among groups in body weight, kidney weight, or glomerular generation number. Nephrogenic zone width was significantly reduced in the Ibuprofen group (123.5 ± 7.4 μm) compared with the 125d gestational control (176.1 ± 6.9 μm) and Untreated animals (169.7 ± 78.8 μm). In the Ibu+NOSi group, nephrogenic zone width averaged 152.7 ± 3.9 μm, which was not significantly different from any other group. Morphologically abnormal glomeruli were present at a range of 0.0–22.9% in the Untreated group, 0.0–6.1% in the Ibuprofen group, and 0.0–1.4% in the Ibu+NOSi group. In conclusion, early postnatal ibuprofen exposure is associated with a reduced nephrogenic zone width, which may suggest the early cessation of nephrogenesis following treatment. Ultimately, this may impact the number of nephrons formed in the preterm kidney. |
Databáze: | OpenAIRE |
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