Virological failure and antiretroviral resistance among HIV-infected children after five years follow-up in the ANRS 12225-PEDIACAM cohort in Cameroon
| Autor: | Mathurin Cyrille Tejiokem, Angeladine Kenne, Ida Calixte Penda, Francis Ateba Ndongo, Jules Brice Tchatchueng Mbougua, Francis Yuya Septoh, Suzie Tetang Ndiang, Josiane Warszawski, Albert Faye, Paul Alain Tagnouokam-Ngoupo, Sorel Jakpou, Jeannine Eboumbou Ngallè |
|---|---|
| Přispěvatelé: | Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Université de Douala, Centre Hospitalier Essos [Yaoundé, Cameroun], Hôpital Laquintinie [Douala, Cameroun], Fondation Chantal Biya (FCB), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This prospective study is sponsored by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS), grants ANRS 12140 and 12225 to MCT. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
Male Pediatrics [SDV]Life Sciences [q-bio] HIV Infections Drug resistance Pathology and Laboratory Medicine Geographical Locations Families chemistry.chemical_compound 0302 clinical medicine Immunodeficiency Viruses Interquartile range Medicine and Health Sciences Public and Occupational Health Cameroon Prospective Studies Treatment Failure 030212 general & internal medicine Children Virus Testing 0303 health sciences Multidisciplinary Pharmaceutics virus diseases Lamivudine Viral Load Vaccination and Immunization 3. Good health Medical Microbiology Viral Pathogens Rilpivirine Viruses Cohort Medicine Drug Therapy Combination Female Pathogens HIV drug resistance Research Article Maternal Age medicine.drug Adult medicine.medical_specialty Nevirapine Efavirenz Anti-HIV Agents Science Immunology Antiretroviral Therapy Microbiology 03 medical and health sciences Antiviral Therapy Drug Therapy Diagnostic Medicine Virology Retroviruses Drug Resistance Viral medicine Humans Microbial Pathogens 030306 microbiology business.industry Lentivirus Organisms Biology and Life Sciences HIV Infant Infectious Disease Transmission Vertical chemistry Age Groups People and Places Africa HIV-1 Population Groupings Preventive Medicine business Viral Transmission and Infection Follow-Up Studies |
| Zdroj: | PLoS ONE, Vol 16, Iss 3, p e0248642 (2021) PLoS ONE PLoS ONE, Public Library of Science, 2021, 16 (3), pp.e0248642. ⟨10.1371/journal.pone.0248642⟩ |
| ISSN: | 1932-6203 |
| Popis: | Objective In the present study, we aimed to evaluate the virological failure (VF) and drug resistance among treated HIV-infected children after five years follow-up in the ANRS-Pediacam cohort in Cameroon. Methods From November 2007 to October 2011, HIV-infected children born to HIV-infected mothers were included in the ANRS-PEDIACAM study and followed-up for more than 5 years. Plasma viral load (VL) was measured at each visit (every three months until month 24 and every 6 months thereafter). VF was the main outcome and HIV drug resistance test was performed using the ANRS procedures and algorithm. Results Data from 155 children were analyzed. The median age at combination antiretroviral therapy (cART) initiation was 4.2 months (interquartile range (IQR): 3.2–5.8), with 103 (66.5%) children taking LPV/r-containing regimen and 51 (32.9%) children taking NVP. After five years follow-up, 63 (40.6%; CI: 32.9–48.8) children experienced VF. The median duration between cART initiation and VF was 22.1 months (IQR: 11.9–37.1) with a median VL of 4.8 log10 (IQR: 4.0–5.5). Among the 57 children with HIV drug resistance results, 40 (70.2%) had at least one drug resistance mutation. The highest resistance rates (30.4–66.1%) were obtained with Lamivudine; Efavirenz; Nevirapine and Rilpivirine. Conclusions These results show high resistance to NNRTI and emphasize the need of VL and resistance tests for optimal follow-up of HIV-infected people especially children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|