A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells
| Autor: | Zhao-Yang Wang, Jie Cui, Jun-Ying Miao, Dong-Peng Li, Xiang-Jian Cao, Bao-Xiang Zhao, Xin Wang, Hao-Zhong Cui |
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| Rok vydání: | 2016 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Endogeny 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Materials Chemistry medicine Fluorescence Resonance Energy Transfer Humans Sulfur Dioxide Fluorescent Dyes Chemistry Metals and Alloys Cancer General Chemistry Hep G2 Cells 021001 nanoscience & nanotechnology medicine.disease Fluorescence 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Mitochondria Bisulfite Förster resonance energy transfer Biochemistry Cancer cell Ceramics and Composites 0210 nano-technology Liver cancer HeLa Cells |
| Zdroj: | Chemical communications (Cambridge, England). 52(13) |
| ISSN: | 1364-548X |
| Popis: | A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3(-)/SO3(2-)) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3(-)/SO3(2-). Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells. |
| Databáze: | OpenAIRE |
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