Circular RNA in tumor metastasis
| Autor: | YiCheng Sun, RongFang Ding, Chang Wen, Huijun Wang, Honghao Chen, WeiNan Lai, Si Tong Huo, Alina He, William W. Du, Chao Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Review Biology medicine.disease_cause Metastasis 03 medical and health sciences 0302 clinical medicine Circular RNA Drug Discovery Gene expression microRNA medicine cancer metastasis Regulation of gene expression lcsh:RM1-950 RNA circular RNA medicine.disease 030104 developmental biology lcsh:Therapeutics. Pharmacology Tumor progression 030220 oncology & carcinogenesis Cancer research Molecular Medicine Carcinogenesis gene regulation |
| Zdroj: | Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 1243-1257 (2021) Molecular Therapy. Nucleic Acids |
| ISSN: | 2162-2531 |
| Popis: | Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed. Graphical Abstract Large numbers of differentially expressed circRNAs have been identified in tumors and metastasis. Gain-of-function and loss-of-function approaches have been developed to manipulate specific circRNA expression in order to modulate tumor development. circRNAs may be used as potential biomarkers for early diagnosis and may be targets for therapeutic strategies. |
| Databáze: | OpenAIRE |
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