N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
| Autor: | Fariba Nanbakhsh, Masoomeh Hajshafiha, Tahereh Behrouzi Lak, Sima Oshnouei |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Intrauterine insemination lcsh:QH471-489 N-acetyl cysteine media_common.quotation_subject medicine.medical_treatment Ovulation induction Insemination lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Internal medicine Follicular phase medicine lcsh:Reproduction 030212 general & internal medicine Ovulation lcsh:RG1-991 Polycystic ovary syndrome media_common Gynecology Pregnancy 030219 obstetrics & reproductive medicine business.industry Letrozole Obstetrics and Gynecology medicine.disease Polycystic ovary Pregnancy rate Endocrinology Reproductive Medicine Original Article business medicine.drug |
| Zdroj: | International Journal of Reproductive Biomedicine Scopus-Elsevier International Journal of Reproductive BioMedicine, Vol 15, Iss 4, Pp 203-208 (2017) ResearcherID |
| ISSN: | 2476-4108 |
| Popis: | Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citrate for ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination. Materials and Methods: In this randomized clinical trial, 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, recombinant human follicle stimulating hormone (r-hFSH; Gonal-F®) was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, 10000 IU human chorionic gonadotropin was injected intramuscular and the intrauterine insemination was performed after 34-36 hr. Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), the mean number of mature follicles (p=0.20), and the pregnancy rate (p=0.09). Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients. |
| Databáze: | OpenAIRE |
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