Mutual regulation of the Hippo/Wnt/LPA/TGF-β signaling pathways and their roles in glaucoma (Review)
| Autor: | Ping Qi, Shaoping Deng, Wei Shi, Yuande Liu, Hailian Wang, Guoli Huai, Yi Wang, Xin Wang, Jie Peng, Hongji Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
animal structures genetic structures Cellular differentiation Yes-associated protein Models Biological 03 medical and health sciences Wnt Hippo Transforming Growth Factor beta Genetics medicine Animals Humans Hippo signaling pathway biology Wnt signaling pathway transforming growth factor-β Glaucoma General Medicine Transforming growth factor beta Articles Cell cycle Cell biology Wnt Proteins 030104 developmental biology medicine.anatomical_structure biology.protein transcriptional co-activator with PDZ-binding motif Trabecular meshwork sense organs Signal transduction Lysophospholipids lysophosphatidic acid Transforming growth factor Signal Transduction |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | Glaucoma is the leading cause of irreversible blindness worldwide and there is no effective treatment thus far. The trabecular meshwork has been identified as the major pathological area involved. Certain signaling pathways in the trabecular meshwork, including the Wnt, lysophosphatidic acid and transforming growth factor‑β pathways, have been identified as novel therapeutic targets in glaucoma treatment. Meanwhile, it has been reported that key proteins in these pathways, particularly the primary transcription regulator Yes‑associated protein (YAP) and transcriptional co‑activator with PDZ‑binding motif (TAZ), exhibit interactions with the Hippo pathway. The Hippo pathway, which was first identified in Drosophila, has drawn great focus with regard to various aspects of studies in recent years. One role of the Hippo pathway in the regulation of organ size was indicated by more recent evidence. Defining the relevant physiological function of the Hippo pathway has proven to be extremely complicated. Studies have ascribed a role for the Hippo pathway in an overwhelming number of processes, including cell proliferation, cell death and cell differentiation. Therefore, the present review aimed to unravel the roles of YAP and TAZ in the Hippo pathway and the pathogenesis of glaucoma. Furthermore, a new and creative study for the treatment of glaucoma is provided. |
| Databáze: | OpenAIRE |
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