Streptococcus suis serotype 2 strains isolated in Argentina (South America) are different from those recovered in North America and present a higher risk for humans
| Autor: | Monica Prieto, Jianguo Xu, Raquel Callejo, Jean-Philippe Auger, Han Zheng, Gustavo Zielinski, Pengcheng Du, Marcelo Gottschalk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Serotype Central Nervous System Streptococcus suis Serotypes Swine Veterinary Microbiology Case Report multilocus sequence typing Zoonosis Zoonoses Genotype Pathogen 2. Zero hunger Molecular Epidemiology Streptococcus suis serotype 2 Virulence biology sequencing 3. Good health Mankind Risk Microbiology (medical) América del Norte Virulence Factors 030106 microbiology Argentina Riesgo Microbiology 03 medical and health sciences medicine Meningitis Cerdo Genomic Sequencing Virulencia Género Humano Streptococcus swine zoonosis biology.organism_classification medicine.disease Virology 030104 developmental biology Multilocus sequence typing Serotipos |
| Zdroj: | JMM Case Reports JMM Case Reports 3 (5) : 1-7 (2016) INTA Digital (INTA) Instituto Nacional de Tecnología Agropecuaria instacron:INTA |
| ISSN: | 2053-3721 |
| Popis: | Introduction: Streptococcus suis serotype 2 is an important swine pathogen and emerging zoonotic agent causing meningitis and septicemia/septic shock. Strains are usually virulent (Eurasia) or of intermediate/low virulence (North America). Very few data regarding human and swine isolates from South America are available. Case presentation: Seventeen new human S. suis cases in Argentina (16 serotype 2 strains and a serotype 5 strain) are reported. Alongside, 14 isolates from pigs are analyzed: 12 from systemic disease, one from lungs and one from tonsils of a healthy animal. All human serotype 2 strains and most swine isolates are sequence type (ST) 1, as determined by multilocus sequence typing and present a mrp+/epf+/sly + genotype typical of virulent Eurasian ST1 strains. The remaining two strains (recovered from swine lungs and tonsils) are ST28 and possess a mrp+/epf − /sly− genotype typical of low virulence North American strains. Representative human ST1 strains as well as one swine ST28 strain were analyzed by whole-genome sequencing and compared with genomes from GenBank. ST1 strains clustered together with three strains from Vietnam and this cluster is close to another one composed of 11 strains from the United Kingdom. Conclusion: Close contact with pigs/pork products, a good surveillance system, and the presence of potentially virulent Eurasian-like serotype 2 strains in Argentina may be an important factor contributing to the higher number of human cases observed. In fact, Argentina is now fifth among Western countries regarding the number of reported human cases after the Netherlands, France, the UK and Poland. EEA Marcos Juárez Fil: Callejo, Raquel. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Han, Zheng. National Institute for Communicable Disease Control and Prevention. Chinese Center for Disease Control. State Key Laboratory for Infectious Disease Prevention and Control. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; China Fil: Pengcheng, Du. Beijing Ditan Hospital. Institute of Infectious Diseases.Capital Medical University. Beijing Key Laboratory of Emerging Infectious Diseases; China Fil: Prieto, Monica. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Jianguo, Xu. National Institute for Communicable Disease Control and Prevention. Chinese Center for Disease Control. State Key Laboratory for Infectious Disease Prevention and Control. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; China Fil: Zielinski, Gustavo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina Fil: Auger, Jean-Philippe. University of Montreal. Faculty of Veterinary Medicine. Swine and Poultry Infectious Disease Center (CRIPA); Canada Fil: Gottschalk, Marcelo. University of Montreal. Faculty of Veterinary Medicine. Swine and Poultry Infectious Disease Center (CRIPA); Canada |
| Databáze: | OpenAIRE |
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