Biochemical composition of human peripheral arteries examined with nearinfrared Raman spectroscopy

Autor: Michael S. Feld, Arnold Miller, Juha Salenius, Barry Sacks, Ramachanda R. Dasari, Thomas Aretz, Yang Wang, James F. Brennan
Rok vydání: 1998
Předmět:
Carotid Artery Diseases
Pathology
Arteriosclerosis
Coronary Disease
Femoral artery
030204 cardiovascular system & hematology
Spectrum Analysis
Raman
030218 nuclear medicine & medical imaging
0302 clinical medicine
Nuclear magnetic resonance
Biochemical composition
Medicine
Single-Blind Method
Coloring Agents
Hematoxylin
Peripheral Vascular Diseases
Spectroscopy
Near-Infrared
Histocytochemistry
Fatty Acids
Calcinosis
Coronary Vessels
3. Good health
Peripheral
Femoral Artery
Carotid Arteries
Cholesterol
medicine.anatomical_structure
symbols
Eosine Yellowish-(YS)
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Sensitivity and Specificity
Lesion
03 medical and health sciences
symbols.namesake
medicine.artery
Humans
Spectroscopy
Fluorescent Dyes
Rupture
Spontaneous
business.industry
Vascular disease
Reproducibility of Results
medicine.disease
Coronary arteries
Durapatite
ROC Curve
Calcium
Surgery
business
Raman spectroscopy
Foam Cells
Zdroj: Journal of Vascular Surgery. 27(4):710-719
ISSN: 0741-5214
DOI: 10.1016/s0741-5214(98)70237-x
Popis: Purpose : Near-infrared Raman spectroscopy provides an important new means of analyzing the chemical composition of the arterial wall. The objective of this study was to show that Raman spectroscopy can be used to evaluate the lipid and calcium salt contents of human peripheral arteries. The results extend a recently developed Raman-based method for analyzing the chemical composition of coronary arteries. Methods and Results : We studied 167 segments of carotid and femoral artery wall in various pathologic states. The Raman spectra from these samples was accurately modeled. The resulting chemical concentrations were compared with the amounts of cholesterol and calcium mineral determined at histologic evaluation by an experienced cardiovascular pathologist. Strong correlations between spectroscopic measurements and morphologic findings were demonstrated and validated the applicability of the method to peripheral arteries. Conclusions : Raman spectroscopy can provide reliable histochemical information about peripheral and coronary arteries. Such information may help identify rupture-prone plaques before the onset of symptoms and allow aggressive and directed intervention. Accurate knowledge of the chemical composition of a lesion may be useful in selecting the most appropriate treatment. (J Vasc Surg 1998;27:710-9.)
Databáze: OpenAIRE
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