Novel fluoride rechargeable dental composites containing MgAl and CaAl layered double hydroxide (LDH)
| Autor: | Andrew J. Bushby, Agron Hoxha, Mangala P. Patel, Natalia Karpukhina, Amani Agha, David G. Gillam |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Diffusion 02 engineering and technology engineering.material 03 medical and health sciences chemistry.chemical_compound Fluorides 0302 clinical medicine Flexural strength Desorption Hydroxides General Materials Science Solubility General Dentistry Minerals Layered double hydroxides 030206 dentistry 021001 nanoscience & nanotechnology chemistry Mechanics of Materials engineering Hydroxide Absorption (chemistry) 0210 nano-technology Fluoride Nuclear chemistry |
| Zdroj: | Dental materials : official publication of the Academy of Dental Materials. 36(8) |
| ISSN: | 1879-0097 |
| Popis: | This study aims to incorporate 2:1 MgAl and 2:1 CaAl layered double hydroxides (LDHs) in experimental dental-composites to render them fluoride rechargeable. The effect of LDH on fluoride absorption and release, and their physico-mechanical properties are investigated.2:1 CaAl and 2:1 MgAl LDH-composite discs prepared with 0, 10 and 30wt% LDH were charged with fluoride (48h) and transferred to deionized water (DW)/artificial saliva (AS). Fluoride release/re-release was measured every 24h (ion-selective electrodes) with DW/AS replaced daily, and samples re-charged (5min) with fluoride every 2 days. Five absorption-release cycles were conducted over 10 days. CaAl and MgAl LDH rod-shaped specimens (dry and hydrated; 0, 10 and 30wt%) were studied for flexural strength and modulus. CaAl and MgAl LDH-composite discs (0, 10, 30 and 45wt% LDH) were prepared to study water uptake (over 7 weeks), water desorption (3 weeks), diffusion coefficients, solubility and cation release (ICP-OES).CaAl LDH and MgAl LDH-composites significantly increased the amount of fluoride released in both media (P0.05). In AS, the mean release after every recharge was greater for MgAl LDH-composites compared to CaAl LDH-composites (P0.05). After every recharge, the fluoride release was greater than the previous release cycle (P0.05) for all LDH-composites. Physico-mechanical properties of the LDH-composites demonstrated similar values to those reported in literature. The solubility and cation release showed a linear increase with LDH loading.LDH-composites repeatedly absorbed/released fluoride and maintained desired physico-mechanical properties. A sustained low-level fluoride release with LDH-composites could lead to a potential breakthrough in preventing early stage carious-lesions. |
| Databáze: | OpenAIRE |
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