Pharmacokinetics of intramuscular nicomorphine and its metabolites in man
| Autor: | G. M. M. Nijhuis, R. Dirksen, P. M. Koopman-Kimenai, Tom B. Vree, L. H. D. J. Booij |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Time Factors Premedication Metabolite Absorption (skin) Pharmacology Injections Intramuscular chemistry.chemical_compound Pharmacokinetics medicine Humans Pharmacology (medical) Morphine Derivatives Morphine Morphine derivatives Nicotinic Acids Half-life General Medicine Middle Aged Nicomorphine chemistry Female Half-Life medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 41:375-378 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00314971 |
| Popis: | After i.m. injection nicomorphine is relatively slowly absorbed from the muscular depot and is found in the serum for approximately 1 h. The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound. The relative AUCs were nicomorphine 18%, 6-nicotinoylmorphine 17%, and morphine 65%. Nicomorphine and 6-nicotinoylmorphine have significantly higher AUCs after i.m. injection than after i.v. injection, while the AUC of morphine and the total AUC show no difference between the two modes of administration. |
| Databáze: | OpenAIRE |
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