Post-natal decline of fetal haemoglobin in homozygous sickle cell disease: relationship to parenteral Hb F levels
| Autor: | Beryl E. Serjeant, William G. Wood, Richard J. Hayes, Yvonne Grandison, Graham R. Serjeant, Karlene Mason, S. Vaidya And |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Linkage disequilibrium medicine.medical_specialty Adolescent Cell Anemia Sickle Cell Biology Disease Relationship Sex Factors Internal medicine Fetal hemoglobin Genotype Fetal haemoglobin medicine Humans Child Fetal Hemoglobin Genetics Fetus Age Factors Infant Newborn Infant Hematology medicine.anatomical_structure Endocrinology Child Preschool Cohort Female |
| Zdroj: | British journal of haematology. 52(3) |
| ISSN: | 0007-1048 |
| Popis: | The decline of fetal haemoglobin (Hb F) from birth to 6 years has been compared in a cohort of 266 Jamaican children with homozygous sickle cel (SS) disease and in 243 matched controls with a normal haemoglobin (AA) genotype. Hb F levels were significantly higher in the SS cases from 1 month onward but, unlike the normal controls, no sex difference was apparent. The Hb F levels in SS disease were significantly correlated with parental Hb F levels, suggesting that genetic factors regulating adult Hb F levels are active at earlier stages in development. Furthermore, some of these genetic determinants of Hb F production may be linked to the beta-like globin gene complex and be in linkage disequilibrium with the beta s allele. |
| Databáze: | OpenAIRE |
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