Functional connection between the stereotyped behavior and the motor front area in children with autism
| Autor: | Chao Chen, Xiao-Hui Liu, Hua Chen, Xin Hou, Dong Wang, Zeng-Jun Zhang, Kun Xia, Ming-Xia Huang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
genetic structures business.industry media_common.quotation_subject Functional connectivity General Medicine medicine.disease behavioral disciplines and activities 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Perception mental disorders Attention deficit Medicine Autism Surgery Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery media_common |
| Zdroj: | British journal of neurosurgery. |
| ISSN: | 1360-046X |
| Popis: | Autism spectrum disorders (ASD) is characterized by stereotyped behavior, attention deficit and/or impaired sensory perception to external stimuli. Its neurobiological mechanisms remain unclear. In this study we examined the resting-state functional connectivity of the premotor area and investigated its correlation with behavioral variables to determine whether connectivity alterations can distinguish ASD from healthy controls.39 children with ASD and 42 healthy children with matched age, sex and intelligence were recruited. All the 81 subjects had behavioral index evaluation and underwent resting-state functional magnetic resonance imaging (fMRI) scans. After MRI data preprocessing, the left and right premotor areas were selected as region of interest (ROI) seeds to perform functional connectivity. Groups were compared, and the correlation between functional connectivity and behavioral indicators was analyzed.Compared with healthy controls, ASD children showed significantly increased functional connectivity between the left premotor area and the posterior cingulate gyrus or anterior lobe of wedge, but functional connectivity between the left premotor area and the left insular lobe was decreased (p 0.05, FDR correction). In addition, the connectivity between the left premotor area and the left insular lobe was negatively correlated with the behavioral scores (p 0.05).Imbalanced premotor functional connectivity may be one possible mechanism of stereotyped behavior in ASD. |
| Databáze: | OpenAIRE |
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