Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

Autor: Kozakova, M, Natali, A, Dekker, J, Beck Nielsen, H, Laakso, M, Nilsson, P, Balkau, B, Ferrannini, E, Heine, Rj, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie Dundee JR, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, Filippo, Saturni, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, Dekker, Ferrannini, Mari, A, Natali, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L.
Přispěvatelé: Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes
Rok vydání: 2013
Předmět:
Zdroj: Kozakova, M, Natali, A, Dekker, J, Beck-Nielsen, H, Laakso, M, Nilsson, P, Balkau, B, Ferrannini, E & RISC Investigators* 2013, ' Insulin sensitivity and carotid intima-media thickness : relationship between insulin sensitivity and cardiovascular risk study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 6, pp. 1409-1417 . https://doi.org/10.1161/ATVBAHA.112.300948
Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1409-1417. Lippincott Williams and Wilkins
Kozakova, M, Natali, A, Dekker, J M, Beck-Nielsen, H, Laakso, M, Nilsson, P, Balkau, B & Ferrannini, E 2013, ' Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 6, pp. 1409-1417 . https://doi.org/10.1161/ATVBAHA.112.300948
ISSN: 1079-5642
DOI: 10.1161/atvbaha.112.300948
Popis: Objective— Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results— We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intima-media thickness in the common carotid artery (CCA-IMT) was significantly higher ( P P Conclusions— In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.
Databáze: OpenAIRE
Externí odkaz: