| Autor: |
Graeme J. Poston, B. A. Taylor, Zoya Galzie, S Gagandeep, B Green, Robert Sutton, Anne R Kinsella |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
International journal of oncology. 8(1) |
| ISSN: |
1019-6439 |
| Popis: |
Basic fibroblast growth factor (bFGF) has been shown to be a potent mitogen for a variety of cell types including colonic epithelial cells. Basic FGF has also been reported to have angiogenic activity. Thus, it has been proposed that bFGF expression might correlate with invasiveness and prognosis in human carcinomas. In the present study, bFGF expression has been evaluated in samples from 44 patients with large bowel carcinoma. Samples from the tumours and corresponding normal mucosae were collected at the time of surgery and frozen sections evaluated using a chick polyclonal antibody to bFGF and standard immunoperoxidase techniques. The expression of bFGF was significantly less within the tumours than in the corresponding normal mucosa (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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