Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity
| Autor: | Marcus Kelm, Andreas Krause, Peter Linz, Vladimir-Andrey Gimenez-Rivera, Florian C. Kurschus, Joanna Wegner, András Maifeld, Elisa Wistorf, Lajos Markó, Dominik N. Müller, Theda Bartolomaeus, Anna Brand, Ralf Dechend, Susanne Karbach, Georgios Kokolakis, Nicola Wilck, Johannes Wild, Natalia Rakova, Ari Waisman, Tine V. Karlsen, Markus Kleinewietfeld, Sandra Philipp, Michael Boschmann, Anna Birukov, Helge Wiig, Björn E. Clausen, Sofia K. Forslund, Michael Schultheis, Titus Kuehne, Friedrich C. Luft, Rebecca Jung |
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| Přispěvatelé: | Wild, Johannes/0000-0002-1446-8101, Wilck, Nicola/0000-0003-3189-5364, Birukov, Anna/0000-0002-8306-3351, Karlsen, Tine, Veronica/0000-0002-1512-2479, Gimenez RIvera, Vladimir, Andrey/0000-0001-5055-208X, Maifeld, Andras, Wild, Johannes, Karlsen, Tine, V, Rakova, Natalia, Wistorf, Elisa, Linz, Peter, Jung , Rebecca, Birukov, Anna, Gimenez-Rivera, Vladimir-Andrey, Wilck, Nicola, Bartolomaeus, Theda, Dechend, Ralf, KLEINEWIETFELD, Markus, Forslund, Sofia K., Krause, Andreas, Kokolakis, Georgios, Philipp, Sandra, Clausen, Bjoern E., Brand , Anna, Waisman, Ari, Kurschus, Florian C., Wegner, Joanna, Schultheis, Michael, Luft, Friedrich C., Boschmann, Michael, Kelm, Marcus, Wiig, Helge, Kuehne, Titus, Muller, Dominik N., Karbach, Susanne, Marko, Lajos |
| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty Sodium chemistry.chemical_element Inflammation Imiquimod Dermatology Sodium Chloride Lymphocyte Activation Severity of Illness Index Biochemistry Article Mice Internal medicine Psoriasis medicine Extracellular Animals Humans T helper 17 cell Molecular Biology Cells Cultured Skin integumentary system business.industry Spectrophotometry Atomic Spectrum Analysis Interleukin-17 Cell Differentiation Cell Biology medicine.disease Pathophysiology Mice Inbred C57BL Endocrinology chemistry Cardiovascular and Metabolic Diseases Th17 Cells medicine.symptom business Intracellular medicine.drug |
| Zdroj: | J Invest Dermatol |
| ISSN: | 0022-202X |
| Popis: | Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17. producing T helper 17 cells play a crucial role. In an observational study, we measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging. Patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASI or healthy controls. Skin sodium concentrations measured by Sodium-23 spectroscopy or by atomic absorption spectrometry in ashed-skin biopsies verified the findings with Sodium-23 magnetic resonance imaging. In vitro T helper 17 cell differentiation of naive CD4(+) cells from patients with psoriasis markedly induced IL-17A expression under increased sodium chloride concentrations. The imiquimod-induced psoriasis mouse model replicated the human findings. Extracellular tracer Chromium-51-EDTA measurements in imiquimod- and sham-treated skin showed similar extracellular volumes, rendering excessive water of intracellular origin. Chronic genetic IL-17A-driven psoriasis mouse models underlined the role of IL-17A in dermal sodium accumulation and inflammation. Our data describe skin sodium as a pathophysiological feature of psoriasis, which could open new avenues for its treatment. |
| Databáze: | OpenAIRE |
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