Molecular pathogenesis of renal cell carcinoma: Impact of the anti-tumormiR-29family on gene regulation
| Autor: | Takayuki Arai, Yukio Naya, Mayuko Kato, Sho Sugawara, Kazuto Yamazaki, Naohiko Seki, Atsushi Okato, Yasutaka Yamada, Tomohiko Ichikawa, Satoko Kojima |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Databases Factual Urology Kaplan-Meier Estimate Pathogenesis 03 medical and health sciences 0302 clinical medicine Japan Cell Movement Renal cell carcinoma Cell Line Tumor microRNA Gene expression medicine Humans Neoplasm Invasiveness Carcinoma Renal Cell HSP47 Heat-Shock Proteins Gene Aged Cell Proliferation Aged 80 and over Regulation of gene expression Gene knockdown business.industry Middle Aged Gene signature medicine.disease Kidney Neoplasms Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female business Genome-Wide Association Study |
| Zdroj: | International Journal of Urology. 25:953-965 |
| ISSN: | 0919-8172 |
| DOI: | 10.1111/iju.13783 |
| Popis: | OBJECTIVES To identify key oncogenes and proteins that are controlled by the microRNA miR-29 family (miR-29a, miR-29b and miR-29c) in renal cell carcinoma pathogenesis. METHODS Genome-wide gene expression and in silico database analyses were carried out. The Cancer Genome Atlas database was used to investigate the clinical significance of gene expression data in renal cell carcinoma patients. Loss-of-function assays were applied to investigate the function of target genes. RESULTS We identified 47 possible target genes that might be regulated by the miR-29 family in renal cell carcinoma cells. Among the targets of the miR-29 family, high expression of 10 genes (ADAMTS14, TRIB13, SERPINH1, FCGR1B, COL1A1, LAIR2, WISP2, TREM1, TNKS1BP1 and GBP2) significantly predicted poor patient prognosis (P |
| Databáze: | OpenAIRE |
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