Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer
| Autor: | Alba Juanes-García, Miguel Vicente-Manzanares, Rocío Aguilar-Cuenca |
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| Rok vydání: | 2013 |
| Předmět: |
Models
Molecular Morphogenesis macromolecular substances Biology Microfilament Mechanotransduction Cellular Cellular and Molecular Neuroscience Cell Movement Myosin Cell Adhesion Animals Homeostasis Humans Mechanotransduction Molecular Biology Actin Cell Proliferation Pharmacology Myosin Type II Cell migration Cell Biology Actin cytoskeleton Actins Cell biology Cell Transformation Neoplastic Molecular Medicine Mechanosensitive channels |
| Zdroj: | Cellular and molecular life sciences : CMLS. 71(3) |
| ISSN: | 1420-9071 |
| Popis: | Mechanotransduction encompasses the role of mechanical forces in controlling cell behavior by activating signal transduction pathways. Most forces at a cellular level are caused by myosin II, which contracts and cross-links actin. Myosin II-dependent forces are transmitted through the actin cytoskeleton to molecular endpoints that promote specific cellular outcomes, e.g., cell proliferation, adhesion, or migration. For example, most adhesive and migratory phenomena are mechanically linked by a molecular clutch comprised of mechanosensitive scaffolds. Myosin II activation and mechanosensitive molecular mechanisms are finely tuned and spatiotemporally integrated to coordinate morphogenetic events during development. Mechanical events dependent on myosin II also participate in tumor cell proliferation, invasion, and metastatic dissemination. Specifically, tumor cells alter the mechanical properties of the microenvironment to create favorable conditions for proliferation and/or dissemination. These observations position myosin II-dependent force generation and mechanotransduction at the crossroads between normal development and cancer. |
| Databáze: | OpenAIRE |
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