Implication of viral microRNAs in the genesis and diagnosis of Epstein‑Barr virus‑associated tumors (Review)
| Autor: | Zunnan Huang, Qianhui Qiu, Biying Zheng, Yudong Ye, Xiangning Zhang, Ming Fu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Review Biology medicine.disease medicine.disease_cause Epstein–Barr virus Virus Lymphoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Nasopharyngeal carcinoma Viral replication hemic and lymphatic diseases 030220 oncology & carcinogenesis microRNA medicine Cancer research Gene |
| Zdroj: | Oncology Letters. |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The Epstein-Barr virus (EBV) is tightly associated with a variety of human tumors, including Burkitt lymphoma and acquired immune deficiency syndrome-related lymphoma of B-cell origin, as well as nasopharyngeal carcinoma and gastric cancer of epithelial origin. The virus latently infects the host cells and expresses proteins and non-coding RNAs to achieve malignancy. MicroRNAs (miRNAs or miRs) are small RNAs consisting of 19–25 nucleotides, which directly bind to the 3′-untranslated region of mRNAs to promote degradation and inhibit translation of mRNAs. EBV-encoded miRs are generated from two regions of the viral genome, within the apoptosis regulator BHRF1 gene locus and near the BamHI A region in a latency type-dependent manner. In addition, EBV-encoded miRs epigenetically regulate the expression of molecules that are effectors of the cell cycle progression, migration, apoptosis and innate immunity, serving a vital role in supporting viral replication and occurrence of EBV-associated tumors. The feasibility of using such miRs as biomarkers for the diagnosis and prognosis of EBV-associated tumors is currently under investigation. |
| Databáze: | OpenAIRE |
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