Biotransformation study of para-substituted phenylpiperazines in Beagle dogs by gas chromatography-mass spectrometry
| Autor: | J.F. Pognat, N Busch, J A Berger, J L Chabard, C. Lartigue-Mattei, M. Bastide, M. J. Galmier |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Pharmacology Chromatography Molecular Structure Trimethylsilyl Chemistry Health Toxicology and Mutagenesis Metabolite General Medicine Toxicology Mass spectrometry Biochemistry Beagle Gas Chromatography-Mass Spectrometry Piperazines chemistry.chemical_compound Dogs NIH shift Biotransformation Animals Gas chromatography Gas chromatography–mass spectrometry |
| Zdroj: | Xenobiotica. 21:1371-1384 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498259109043212 |
| Popis: | 1. Beagle dogs were treated orally (10 mg/kg) with para-chloro-, para-fluoro- and para-methyl-phenylpiperazine derivatives, and urine was collected for 72 h after treatment. 2. Metabolites were extracted, converted into trimethylsilyl (TMS) derivatives and examined by g.l.c.-mass spectrometry. 3. The metabolites fall into two main groups, N-desphenylated metabolites, which result from N-desphenylation, and N-phenyl metabolites. 4. Two kinds of hydroxylated metabolites were found. Some lost the original para substituent (Cl, F or CH3); others retained it. 5. These results are consistent with the NIH shift reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|