Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply
| Autor: | Chris De Savi, Lisbet Kvaerno, David L. Hughes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
supply Coronavirus disease 2019 (COVID-19) synthesis 010405 organic chemistry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Organic Chemistry COVID-19 repurposed drugs Review 010402 general chemistry 01 natural sciences Small molecule 0104 chemical sciences Engineering ethics Business Physical and Theoretical Chemistry Repurposing mechanism of action |
| Zdroj: | Organic Process Research & Development |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.0c00233 |
| Popis: | The outbreak of the COVID-19 pandemic has spurred an intense global effort to repurpose existing approved drugs for its treatment. In this review, we highlight the development of seven small-molecule drugs that are currently being assessed in clinical trials for the treatment of COVID-19. Three sections are presented for each drug: (1) history, mechanism of action, and status of clinical trials; (2) scalable synthetic routes and final forms; and (3) outlook for supply should clinical trials show treatment efficacy. A brief overview of diagnostic testing and vaccine development is also presented. |
| Databáze: | OpenAIRE |
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