Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration
| Autor: | Jenna L. Dziki, Michael L. Boninger, Fabrisia Ambrosio, Brian M. Sicari, Stephen F. Badylak |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biomimetic materials Biophysics Bioengineering 02 engineering and technology Regenerative medicine Biomaterials Extracellular matrix 03 medical and health sciences Tissue engineering Biomimetic Materials Skeletal Muscle Tissue medicine Humans Regeneration Muscle Skeletal Tissue Engineering Tissue Scaffolds Muscle loss Guided Tissue Regeneration business.industry Regeneration (biology) Skeletal muscle Equipment Design 021001 nanoscience & nanotechnology Extracellular Matrix Cell biology 030104 developmental biology medicine.anatomical_structure Mechanics of Materials Ceramics and Composites 0210 nano-technology business Biomedical engineering |
| Zdroj: | Biomaterials. 103:128-136 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2016.06.047 |
| Popis: | Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated. The manuscript also identifies key mechanisms that have been associated with ECM-mediated skeletal muscle repair, and provides hypotheses as to why there have been variable outcomes, ranging from successful to unsatisfactory, associated with ECM bioscaffold implantation in the skeletal muscle injury microenvironment. |
| Databáze: | OpenAIRE |
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