Pilomatrix carcinoma. A case report with immunohistochemical findings, flow cytometric comparison with benign pilomatrixoma and review of the literature
| Autor: | De Rosa G, L. Panico, A. Ruggiero, Manivel Jc, Guido Pettinato, de Rosa N |
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| Přispěvatelé: | Panico, L, Manivel, Jc, Pettinato, Guido, De Rosa, N, Ruggiero, A, DE ROSA, Gaetano |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Adult
0301 basic medicine Peanut agglutinin Cancer Research Pathology medicine.medical_specialty Skin Neoplasms Vimentin S Phase Flow cytometry 03 medical and health sciences Cytokeratin Humans Medicine Pathological 030102 biochemistry & molecular biology biology medicine.diagnostic_test business.industry General Medicine Flow Cytometry Pilomatrixoma Immunohistochemistry 030104 developmental biology Oncology biology.protein Female Hair Diseases Pilomatrix carcinoma business |
| Zdroj: | Scopus-Elsevier |
| Popis: | We report a case of pilomatrix carcinoma in a 42 year old woman. The patient presented a rapidly growing 4-cm subcutaneous mass in the right preauricular area. She was free of recurrence 24 months after surgery. Immunoreactivity was studied for cytokeratins, epithelial membrane antigen, S-100 protein, blood group antigens, Leu-M1, β-2-microglobulin, vimentin, neuron-specific-enolase and cellular binding for peanut agglutinin. Squamous cells were reactive for cytokeratin AE1/3, epithelial membrane antigen, blood group antigens B and H, and peanut agglutinin. Basaloid cells were focally reactive for cytokeratin AE1/3 and epithelial membrane antigen. Flow cytometry revealed a euploid DNA content and a high proliferative rate of the pilomatrix carcinoma and in benign pilomatrixoma studied for comparison. The pathological diagnosis must be based on histomorphological criteria. |
| Databáze: | OpenAIRE |
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