Suppressive Effect of Simvastatin on Intramural Small Coronary Arterial Lesions in Cholesterol-Fed Rabbits
| Autor: | Mami Fukuoka, Seiji Kawazoye, Sei Emura, Hayato Kishikawa, Ryuuichirou Okada, Hiroyuki Kato, Keizo Ohmori, Kazuhisa Oogushi, Toshinobu Takashima |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Simvastatin medicine.medical_specialty medicine.medical_treatment Drug Evaluation Preclinical Coronary Artery Disease Placebo Cholesterol Dietary Lesion Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Chemotherapy Lagomorpha Dose-Response Relationship Drug biology Cholesterol business.industry Anticholesteremic Agents biology.organism_classification Coronary Vessels Coronary arteries Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Enzyme inhibitor Depression Chemical Linear Models biology.protein Diet Atherogenic Rabbits medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Angiology. 49:211-220 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331979804900307 |
| Popis: | The aim of this study was to examine the suppressive effect of simvastatin on intramural coronary arterial lesions in cholesterol-fed rabbits. In one experiment, six groups of rabbits were fed laboratory chow alone or with added 0.1%, 0.2%, 0.3%, 0.5% or 1.0% cholesterol for 16 weeks. In another experiment, four groups of rabbits were fed a 0.5% cholesterol diet and treated with simvastatin at 1, 3, or 5 mg/kg/day or placebo. In each rabbit, the levels of serum total cholesterol (TC) were determined at 1-week intervals to calculate the integrated values. The lesion induction ratio was defined as the ratio of intramural coronary arteries 50-150 μm in diameter with arterial lipoidosis to the total number of arteries of the same diameter. In the two experiments, there were positive correlations between the lesion induction ratio and integrated TC (r=0.785, P < 0.0001 and r=0.763, P |
| Databáze: | OpenAIRE |
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