Safety and immunogenicity of inactivated, Vero cell culture-derived whole virus influenza A/H5N1 vaccine given alone or with aluminum hydroxide adjuvant in healthy adults
| Autor: | James D. Campbell, Heather Hill, Cornelia L. Dekker, Kuo Guo, Helen Talbot, Shital M. Patel, Kathryn M. Edwards, Dora Y. Ho, Diana L. Noah, ChrisAnna M. Mink, Wendy A. Keitel |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent H5N1 vaccine Influenza vaccine medicine.medical_treatment Orthomyxoviridae Dose-Response Relationship Immunologic Aluminum Hydroxide Biology Antibodies Viral medicine.disease_cause Article Young Adult Adjuvants Immunologic Double-Blind Method Neutralization Tests Chlorocebus aethiops Influenza Human Influenza A virus medicine Animals Humans Neutralizing antibody Vero Cells Influenza A Virus H5N1 Subtype General Veterinary General Immunology and Microbiology Immunogenicity Public Health Environmental and Occupational Health Hemagglutination Inhibition Tests biology.organism_classification Virology Vaccination Infectious Diseases Influenza Vaccines Immunology biology.protein Molecular Medicine Female Adjuvant |
| Zdroj: | Vaccine. 27:6642-6648 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2009.03.015 |
| Popis: | Dosage-sparing strategies, adjuvants and alternative substrates for vaccine production are being explored for influenza vaccine development. We assessed the safety and immunogenicity of a Vero cell culture-grown inactivated whole virus influenza A/H5N1 vaccine with or without aluminum hydroxide adjuvant [Al(OH)(3)] in healthy young adults. Vaccines were well tolerated, but injection site discomfort was more frequent in groups receiving Al(OH)(3). Dose-related increases in serum antibody levels were observed. Neutralizing antibody titers varied significantly when tested by two different laboratories. Al(OH)(3) did not enhance HAI or neutralizing antibody responses, and contributed to increased injection site pain. Because influenza antibody titers vary significantly between different laboratories, international standardization of assays is warranted. |
| Databáze: | OpenAIRE |
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