Targeting Alzheimer’s Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment
| Autor: | Hua Zhang, Pedro Rosa-Neto, Tharick A. Pascoal, Kok Pin Ng, Serge Gauthier |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tau hyperphosphorylation medicine.medical_specialty diagnosis precision medicine media_common.quotation_subject database analysis brain imaging Relative weight Translational research Review Disease 03 medical and health sciences 0302 clinical medicine Optimism Neuroimaging Alzheimer Disease medicine Animals Humans Intensive care medicine media_common treatment business.industry General Neuroscience biomarkers General Medicine human volunteer cohorts Precision medicine medicine.disease 3. Good health Psychiatry and Mental health Clinical Psychology 030104 developmental biology translational research Geriatrics and Gerontology Alzheimer's disease business Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-179924 |
| Popis: | Cautious optimism is appropriate for a near future (five years) time frame for a number of drugs acting on the different pathophysiological components of Alzheimer's disease (amyloid deposition, tau hyperphosphorylation, neuroinflammation, vascular changes, to name the most important known so far). Since the relative weight of these components will be different between individuals and will even change over time for each individual, a 'one drug fit for all' approach is no longer defensible. Precision medicine using biomarkers in the diagnosis and treatment of Alzheimer's disease is the new strategy. |
| Databáze: | OpenAIRE |
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