Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles

Autor:	Sayumi Yamasaki, Motoi Todoroki, Shigehisa Endoh, Takako Oyabu, Isamu Tanaka, Masami Hirohashi, Kunio Uchida, Chikara Kadoya, Hiroko Nagatomo, Makoto Yamamoto, Yasuo Morimoto, Katsuhide Fujita, Masahiro Murakami, Junko Nakanishi, Toshihiko Myojo, Norihiro Kobayashi, Akira Ogami, Kazuhiro Yamamoto, Kenichiro Nishi
Rok vydání:	2010
Předmět:	Male Chemokine Pathology medicine.medical_specialty Materials science Biomedical Engineering Inflammation Lung injury Toxicology Microscopy Electron Transmission Fibrosis Nickel Macrophages Alveolar medicine Intubation Intratracheal Macrophage Animals Particle Size Rats Wistar Lung biology Monocyte Nickel oxide Pneumonia respiratory system medicine.disease respiratory tract diseases Rats Disease Models Animal medicine.anatomical_structure Instillation Drug biology.protein Cytokines Nanoparticles medicine.symptom Bronchoalveolar Lavage Fluid
Zdroj:	Nanotoxicology. 4(2)
ISSN:	1743-5404
Popis:	The objective of this study was to examine what kinds of cytokines are related to lung disorder by well-dispersed nanoparticles. The mass median diameter of nickel oxide in distilled water was 26 nm. Rats intratracheally received 0.2 mg of nickel oxide suspended in distilled water, and were sacrificed from three days to six months. The concentrations of 21 cytokines including inflammation, fibrosis and allergy-related ones were measured in the lung. Infiltration of alveolar macrophages was observed persistently in the nickel oxide-exposed group. Expression of macrophage inflammatory protein-1alpha showed a continued increase in lung tissue and broncho-alveolar lavage fluid (BALF) while interleukin-1alpha (IL-1alpha), IL-1beta in lung tissue and monocyte chemotactic protein-1 in BALF showed transient increases. Taken together, it was suggested that nano-agglomerates of nickel oxide nanoparticles have a persistent inflammatory effect, and the transient increase in cytokine expression and persistent increases in CC chemokine were involved in the persistent pulmonary inflammation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102f7a71ca1d6329a1446ae1529aa12b https://pubmed.ncbi.nlm.nih.gov/20795893 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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