Bilateral morphometric analysis of corneal sub-basal nerve plexus in patients undergoing unilateral cataract surgery: a preliminary in vivo confocal microscopy study
| Autor: | Federica Turchi, Aldo Vagge, Fabio Guaraldi, Carlo Torrazza, Piera Versura, Luca Di Cello, Vincenzo Scorcia, Marco Pellegrini, Carlo Enrico Traverso, Riccardo Scotto, Federico Bernabei, Carlotta Senni, Daniele Sindaco, Giuseppe Giannaccare |
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| Přispěvatelé: | Giannaccare G., Bernabei F., Pellegrini M., Guaraldi F., Turchi F., Torrazza C., Senni C., Scotto R., Sindaco D., Di Cello L., Versura P., Scorcia V., Traverso C.E., Vagge A. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment In vivo confocal microscopy Ophthalmic Nerve NO Cellular and Molecular Neuroscience Basal (phylogenetics) Nerve Fibers Lens Implantation Intraocular Cornea cornea Humans Medicine In patient Prospective Studies Aged diagnostic tests/investigation imaging Aged 80 and over Microscopy Confocal Phacoemulsification business.industry Cornea imaging diagnostic tests/investigation Nerve plexus Unilateral cataract Cataract surgery Sensory Systems Surgery Ophthalmology medicine.anatomical_structure Autonomic Nervous System Diseases Morphometric analysis Female business |
| Popis: | AimsTo evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.MethodsIVCM was performed before (V0) and 1 month after surgery (V1) in both operated eyes (OEs) and unoperated eyes (UEs) of 30 patients. Thirty age and sex-matched subjects acted as controls. Corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD), corneal nerve fibre length (CNFL), corneal nerve total branch density (CTBD), corneal nerve fibre area (CNFA), corneal nerve fibre width, corneal nerve fractal dimension (CNFrD) and dendritic cells density were calculated.ResultsMean CNFD, CNBD, CNFL, CTBD, CNFA and CNFrD significantly decreased at V1 versus V0 in both eyes (respectively, 15.35±7.00 vs 21.21±6.56 n/mm2 in OEs and 20.11±6.69 vs 23.20±7.26 in UEs; 13.57±12.16 vs 26.79±16.91 n/mm2 in OEs and 24.28±14.88 vs 29.76±15.25 in UEs; 9.67±3.44 mm/mm2 vs 13.49±3.42 in OEs and 12.53±3.60 vs 14.02±3.82 in UEs; 22.81±18.77 vs 42.25±24.64 n/mm2 in OEs and 38.06±20.52 vs 43.93±22.27 in UEs; 0.0040±0.0021 vs 0.0058±0.0020 mm2/mm2 in OEs and 0.0049±0.0016 vs 0.0057±0.0019 in UEs; 1.418±0.058 vs 1.470±0.037 in OEs and 1.466±0.040 vs 1.477±0.036 in UEs; always pConclusionPatients undergoing cataract surgery exhibit bilateral alterations of CSNP. This finding could have broad implications in the setting of sequential cataract surgery. |
| Databáze: | OpenAIRE |
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