Loss of tissue expression of interleukin-10 promotes the disease progression of colorectal carcinoma
| Autor: | Yasuhiro Inoue, Sayaka Minobe, Chikao Miki, Hiroko Urano, Masato Kusunoki, Yuji Toiyama |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Male Prognostic factor medicine.medical_specialty Colorectal cancer medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Kaplan-Meier Estimate Mouse model of colorectal and intestinal cancer Japan Surgical oncology Risk Factors Internal medicine Confidence Intervals Medicine Humans Intestinal Mucosa Aged Proportional Hazards Models Aged 80 and over business.industry Disease progression General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Interleukin-10 Interleukin 10 Cytokine Tissue expression Case-Control Studies Multivariate Analysis Disease Progression Surgery Female business Colorectal Neoplasms |
| Zdroj: | Surgery today. 40(1) |
| ISSN: | 1436-2813 |
| Popis: | Interleukin-10 (IL-10) is a unique cytokine that is thought to be a potent immunostimulatory and immunosuppressive factor. The aim of this study was to investigate IL-10 expression in colorectal cancer, and clarify its relationship to the clinicopathological findings and prognosis.Tissue samples were collected from 92 patients with colorectal cancer and adjacent normal mucosa. The expression of IL-10 in colorectal cancer tissues was evaluated by immunohistochemistry. Tissue levels of IL-10 were measured by enzyme-linked immunosorbent assay.The mean concentration of IL-10 did not significantly differ between the cancer tissue and adjacent normal mucosa. The IL-10 concentration in cancer tissue with positive staining immunohistochemically was significantly higher than that without IL-10 staining. The IL-10 level in cancer tissue decreased in accordance with advanced-stage serosal invasion and lymph node involvement, and thus predicted poor survival in patients undergoing surgery with curative intent. A Cox multivariate analysis demonstrated that a decreased IL-10 level in cancer tissue was an independent risk factor for poor survival.The tumor IL-10 level in colorectal cancer was inversely correlated with serosal invasion and lymph node metastasis, which thus reflected tumor progression. Evaluating the tumor expression of IL-10 may therefore provide valuable information for predicting the long-term survival in patients undergoing surgery with curative intent. |
| Databáze: | OpenAIRE |
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