Relationship between kallikrein and PRA after intravenous furosemide
| Autor: | Simonetti Bm, R. Ronci, Stirati G, F. Taggi, Cinotti Ga, Pierucci A |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Renal function Stimulation urologic and male genital diseases Plasma renin activity Excretion Basal (phylogenetics) Endocrinology Furosemide Internal medicine Renin–angiotensin system Renin medicine Humans cardiovascular diseases urogenital system business.industry Sodium Kallikrein Middle Aged biological factors Kinetics Hypertension Female Kallikreins business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of endocrinological investigation. 2(2) |
| ISSN: | 0391-4097 |
| Popis: | Interrelationships between plasma renin activity (PRA), urinary kallikrein and sodium excretion were studied before and after furosemide iv administration in nine normal volunteers and in one low renin non hypertensive patient. PRA, urinary kallikrein and sodium excretion increased within 15 min of furosemide injection in nine subjects; kallikrein excretion then decreased sharply, whereas plasma renin activity reached peak values within 15–120 min of stimulation. In low renin subject low basal levels of PRA paralleled undetectable values of kallikrein excretion, and PRA and kallikrein excretion showed no increase after furosemide, despite the expected natriuretic response. The following conclusions appear feasible: (i) the natriuretic effect of furosemide is direct and independent of the effect on PRA and urinary kallikrein; (ii) in man, furosemide induces an increase in urinary kallikrein excretion which is immediate, of short duration and simultaneous in all the patients studied; (iii) no statistical correlation is demonstrated between the temporal behavior of urinary kallikrein and PRA; it is however possible that, at least for certain stimuli, renin release is in some way correlated with the activation of the renal kallikrein-bradykinin system. |
| Databáze: | OpenAIRE |
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