Alternative site of implantation affects tumor malignancy and metastatic potential in mice: its comparison to the flank model
| Autor: | Silvia del Valle Alonso, Lucia Speroni, Raúl Alejandro Ruggiero, Maria C. Taira, Julieta Gasparri, Victoria de los Ángeles Bustuoabad, Nadia Silvia Chiaramoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
Flank Pathology medicine.medical_specialty FLANK AND DORSAL REGIO MICE FOOT CIENCIAS MÉDICAS Y DE LA SALUD Fibrosarcoma Melanoma Experimental Inmunología Biology ANIMAL MODEL Malignancy Mice Immune system Dermis MC-C FIBROSARCOMA Cell Line Tumor medicine Animals Neoplasm Invasiveness Neoplasm Metastasis Pharmacology B16F0 MELANOMA TUMORS Tumor microenvironment Back Immunity Cellular Sheep NEOPLASM METASTASIS Foot Melanoma medicine.disease Immunity Innate Survival Rate Disease Models Animal Medicina Básica medicine.anatomical_structure Oncology Tumor progression Disease Progression Molecular Medicine Neoplasm Transplantation |
| DOI: | 10.4161/cbt.8.4.7452 |
| Popis: | MC-C fibrosarcoma and B16F0 melanoma tumors were implanted intradermally in the dorsal region of the foot of mice. Tumor progression was compared to standard implantation in the flank. Although foot tumors only reached 13% (MC-C) and 25% (B16F0) of the mean volume of flank tumors, a more malignant phenotype in terms of histology and survival rate was observed in this type of tumors. Moreover, lung metastases were only detected in hosts bearing foot tumors, in contrast to MC-C and B16F0 populations with tumors growing in the flank. In addition, cellular influx and local immune reaction were higher in the dorsal region of the foot. According to our results, the dermis of the flank allows excessive tumor growth due to its low reactivity. Thus, differences in innate and adaptive immune effectors between the evaluated tumor microenvironments would account for the differences in tumor malignancy. Due to its striking differences with the standard flank inoculation, the tumor implantation model herein introduced could be a valuable tool to study the metastatic potential of different cell lines and the microenvironment components affecting tumor growth. Fil: Speroni, Lucia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bustuoabad, Victoria de los Ángeles. Provincia de Buenos Aires. Municipio Malvinas Argentinas. Hospital Municipal Oftalmológico Malvinas Argentina; Argentina Fil: Gasparri, Julieta. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Chiaramoni, Nadia Silvia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Taira, Maria Cristina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina Fil: Ruggiero, Raul Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Alonso, Silvia del Valle. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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