Nanoparticle Biokinetics in Mice and Nonhuman Primates
| Autor: | Mike Jeon, Zachary R. Stephen, Veronica Nelson, Richard G. Ellenbogen, Miqin Zhang, Richard A. Revia, Kui Wang, Jonathan G. Sham, Forrest M. Kievit, Hans-Peter Kiem, Peter A. Chiarelli |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science General Physics and Astronomy Nanoparticle Nanotechnology 02 engineering and technology Ferric Compounds Article Mice 03 medical and health sciences chemistry.chemical_compound Pharmacokinetics In vivo medicine Animals Tissue Distribution Whole Body Imaging General Materials Science Organ system medicine.diagnostic_test General Engineering Magnetic resonance imaging 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 030104 developmental biology medicine.anatomical_structure chemistry Macaca Nanoparticles Bone marrow 0210 nano-technology Iron oxide nanoparticles Biomedical engineering Large animal |
| Zdroj: | ACS Nano. 11:9514-9524 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.7b05377 |
| Popis: | Despite the preponderance of iron oxide nanoparticles (NPs) designed for theranostic applications, widespread clinical translation of these NPs lags behind. A better understanding of how NP pharmacokinetics vary between small and large animal models is needed to rapidly customize NPs for optimal performance in humans. Here we use noninvasive magnetic resonance imaging (MRI) to track iron oxide NPs through a large number of organ systems in vivo to investigate NP biokinetics in both mice and nonhuman primates. We demonstrate that pharmacokinetics are similar between mice and macaques in the blood, liver, spleen, and muscle, but differ in the kidneys, brain, and bone marrow. Our study also demonstrates that full-body MRI is practical, rapid and cost-effective for tracking NPs non-invasively with high spatiotemporal resolution. Our techniques using a nonhuman primate model may provide a platform for testing a range of NP formulations. |
| Databáze: | OpenAIRE |
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