Visual and semiquantitative analysis of 82Rb uptake in malignant tumors on PET/CT: first systematic analysis
| Autor: | Hemant Desai, Terence Z. Wong, Jorge Oldan, Clayton W. Commander, Amir H. Khandani, Thad Benefield, Marijana Ivanovic |
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| Rok vydání: | 2019 |
| Předmět: |
Blood pool
Subcutaneous fat 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Neoplasms Positron Emission Tomography Computed Tomography medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Rest (music) Positron Emission Tomography-Computed Tomography PET-CT Lung business.industry Biological Transport General Medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine.symptom Nuclear medicine business Semi quantitative Rubidium Radioisotopes |
| Zdroj: | Nuclear medicine communications. 40(5) |
| ISSN: | 1473-5628 |
| Popis: | The objective of this study was to analyze the uptake of rubidium in malignant tumors.Sixteen malignant lesions were included. Two radiologists compared each lesion to four references (subcutaneous fat, lung, mediastinal blood pool, and liver) at rest and stress and scored as 1-4. Maximum standardized uptake value (SUV) in each lesion and four references, as well as ratios of lesion SUV to SUV of each of the references, were calculated at rest and stress. We assessed an agreement for scores of reader 1 versus reader 2 (inter-reader) at rest and stress, scores at rest versus stress (intrapatient) for reader 1 and reader 2, and lesion SUV and respective ratios at rest and stress using paired t-test and Bland-Altman analyses.Fifteen (94%) out of 16 lesions had a score of 3 or 4 at rest or stress or both by at least one reviewer. We did not find evidence of inter-reader bias at rest or stress or intrapatient (rest vs. stress) bias for either reader. SUV ranged from 1.0 to 8.1 at rest and from 0.7 to 6.7 at stress. There was an excellent agreement between ratios of lesion SUV to lung SUV at rest versus stress. On the extreme, there was a poor agreement between ratios of lesion SUV to liver SUV at rest versus stress. Otherwise, the agreement was good for the majority of the results, and moderate for a few others.Malignant tumors can be readily depicted and quantified on rubidium PET/CT. Further research is needed. |
| Databáze: | OpenAIRE |
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