Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen
| Autor: | Erika Lindquist, Richard C. Hamelin, Nicolas Feau, Jasmyn Pangilinan, Bernard Henrissat, Andrea Aerts, Braham Dhillon, Navdeep Gill, Padmini Herath, Ronald P. de Vries, Philippe Tanguay, Eline Majoor, Monique L. Sakalidis, John N. Saddler, Igor V. Grigoriev, Adam Foster, Kurt LaButti, Robin A. Ohm, Amadeus Pribowo, Anthony Levasseur, Stéphanie Beauseigle, Stephen B. Goodwin, Alex Copeland, Louis Bernier |
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| Přispěvatelé: | Architecture et fonction des macromolécules biologiques (AFMB), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Sub Molecular Plant Physiology, Sub Molecular Microbiology, Molecular Plant Physiology |
| Rok vydání: | 2015 |
| Předmět: |
Time Factors
Colony Count Gene Transfer Septoria canker Colony Count Microbial Gene Dosage Indole Alkaloids Trees Microbial Gene Expression Regulation Fungal Gene cluster Fungal genomics ComputingMilieux_MISCELLANEOUS Phylogeny Genome Multidisciplinary [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Structural Biology [q-bio.BM] Ascomycota biology food and beverages Poplar pathogen Biological Sciences [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Adaptation Physiological Wood [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] Fungal Populus Host-Pathogen Interactions Horizontal gene transfer Mycosphaerella Genome Fungal Woody plant Gene Transfer Horizontal Genetic Speciation Nitrogen Physiological Molecular Sequence Data Synteny Gene dosage Horizontal Tree disease Botany medicine Adaptation General Gene Canker Base Sequence fungi biology.organism_classification medicine.disease Gene Expression Regulation Proteolysis |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3451-6. National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (11), pp.3451-3456. ⟨10.1073/pnas.1424293112⟩ Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (11), pp.3451-3456. ⟨10.1073/pnas.1424293112⟩ Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3451. National Academy of Sciences |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems. |
| Databáze: | OpenAIRE |
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