Intraoperative Radiotherapy during Breast Conserving Surgery in Patients Previously Treated with Radiotherapy for Hodgkin's Disease
| Autor: | Alberto Luini, Gabriela Rosali Dos Santos, Umberto Veronesi, Maria Cristina Leonardi, Paolo Veronesi, Guillermo Bassani, Mario Ciocca, Anna Rita Vento, Julia Rodriguez, Mattia Intra, Giovanna Gatti, Roberto Orecchia |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Mammary gland Breast Neoplasms Disease Mastectomy Segmental 030218 nuclear medicine & medical imaging Intraoperative Period 03 medical and health sciences 0302 clinical medicine Breast cancer medicine Breast-conserving surgery Humans Aged business.industry Contraindications Carcinoma Ductal Breast Radiotherapy Dosage General Medicine Middle Aged medicine.disease Hodgkin Disease Lymphoma Surgery Radiation therapy medicine.anatomical_structure Italy Oncology 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant business Intraoperative radiotherapy Mastectomy |
| Zdroj: | Università degli Studi di Milano-IRIS |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089160409000104 |
| Popis: | Aims and background Women who have received radiotherapy for Hodgkin's disease have an increased risk of developing breast cancer. Breast-conserving surgery followed by breast irradiation is generally considered to be contraindicated in such patients owing to the high cumulative radiation dose to the breast. Mastectomy is therefore recommended as the preferred treatment option in these women. Methods We report 3 patients affected by breast cancer who had previously been treated with mantle radiation for Hodgkin's disease and on whom breast-conserving surgery and full-dose intraoperative radiotherapy with electrons (ELIOT) were performed. Results A total dose of 17 Gy (prescribed at 100% isodose) in one case and 21 Gy (at the 90% isodose) in two cases was delivered directly to the mammary gland without acute complications and with good cosmetic results. Conclusions In women previously irradiated for Hodgkin's disease, ELIOT could avoid repeat irradiation of the whole breast, thereby permitting conservative surgical treatment. |
| Databáze: | OpenAIRE |
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