Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
| Autor: | Charles DeCarli, Vilmundur Gudnason, Debra A. Fleischman, Henning Tiemeier, Rebecca F. Gottesman, William S. Kremen, Xueqiu Jian, Henry Brodaty, Maria del C. Valdés Hernández, Markus Loeffler, Reinhold Schmidt, Shahzad Ahmad, Paul A. Nyquist, Oscar L. Lopez, Anbupalam Thalamuthu, Helena Schmidt, Peter R. Schofield, Tonya White, Edith Hofer, Philip L. De Jager, David Ames, Qiong Yang, Ole A. Andreassen, Cora E. Lewis, Matthias Nauck, David S. Knopman, Anders M. Dale, Sven J. van der Lee, Jeroen van der Grond, Konstantinos Arfanakis, Margaret J. Wright, Jingyun Yang, John B.J. Kwok, Hieab H.H. Adams, Matthew S. Panizzon, Meike W. Vernooij, Yasaman Saba, David A. Bennett, Cornelia M. van Duijn, Tamara B. Harris, Pauline Maillard, Frauke Beyer, M. Arfan Ikram, Jerome I. Rotter, Ryan L. Muetzel, Tomáš Paus, Pamela J. Schreiner, Zdenka Pausova, Katharina Wittfeld, Diane M. Becker, Bruce M. Psaty, Alexander Teumer, Wei Wen, A. Veronica Witte, Karen A. Mather, Hanan El Marroun, William T. Longstreth, Perminder S. Sachdev, Mark E. Bastin, Nathan A. Gillespie, Kenneth Rice, Stella Trompet, Lisa R. Yanek, David J. Stott, Alexa S. Beiser, R. Nick Bryan, Alexander Neumann, Natalie A. Royle, Myriam Fornage, Manon Bernard, Dina Vojinovic, Najaf Amin, Ian J. Deary, Arno Villringer, Georg Homuth, Nicola J. Armstrong, Stephen Sidney, Sudha Seshadri, Joanna M. Wardlaw, Thomas H. Mosley, Hans J. Grabe, Michelle Luciano, Lenore J. Launer, J. Wouter Jukema, Robin Bülow, Markus Scholz, André G. Uitterlinden, Albert V. Smith, Shuo Li, Claudia L. Satizabal, Joshua C. Bis |
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| Přispěvatelé: | Epidemiology, Radiology & Nuclear Medicine, Child and Adolescent Psychiatry / Psychology, Clinical Psychology, Internal Medicine, Psychiatry, Neurology, Faculty of Medicine (UI), Læknadeild (HÍ), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands (HÍ), University of Iceland (UI) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Genetics of the nervous system Cytoskeleton organization General Physics and Astronomy Genome-wide association study Mental disorders Genome-wide association studies Genome Lateral ventricles 0302 clinical medicine Lateral Ventricles Ventricle (lateral) lcsh:Science Genetics anatomy & histology [Lateral Ventricles] education.field_of_study Enlargement Multidisciplinary Brain Organ Size Middle Aged Schizophrenia ddc:500 Science Population Elderly people Biology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences medicine Erfðafræði Humans Genomes education Aged Genetic association genetics [Organ Size] Genome Human Heilinn Brain morphometry Litningarannsóknir Rannsóknir General Chemistry medicine.disease 030104 developmental biology Heritable quantitative trait lcsh:Q 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018) Nature Communications, 9(1):3945. Nature Publishing Group Nature Communications 9(1), 3945 (2018). doi:10.1038/s41467-018-06234-w Vojinovic, D, Adams, H H, Jian, X, Yang, Q, Smith, A V, Bis, J C, Teumer, A, Scholz, M, Armstrong, N J, Hofer, E, Saba, Y, Luciano, M, Bernard, M, Trompet, S, Yang, J, Gillespie, N A, van der Lee, S J, Neumann, A, Ahmad, S, Andreassen, O A, Ames, D, Amin, N, Arfanakis, K, Bastin, M E, Becker, D M, Beiser, A S, Beyer, F, Brodaty, H, Bryan, R N, Bülow, R, Dale, A M, De Jager, P L, Deary, I J, DeCarli, C, Fleischman, D A, Gottesman, R F, van der Grond, J, Gudnason, V, Harris, T B, Homuth, G, Knopman, D S, Kwok, J B, Lewis, C E, Li, S, Loeffler, M, Lopez, O L, Maillard, P, El Marroun, H, Mather, K A, Mosley, T H, Muetzel, R L, Nauck, M, Nyquist, P A, Panizzon, M S, Pausova, Z, Psaty, B M, Rice, K, Rotter, J I, Royle, N, Satizabal, C L, Schmidt, R, Schofield, P R, Schreiner, P J, Sidney, S, Stott, D J, Thalamuthu, A, Uitterlinden, A G, Valdés Hernández, M C, Vernooij, M W, Wen, W, White, T, Witte, A V, Wittfeld, K, Wright, M J, Yanek, L R, Tiemeier, H, Kremen, W S, Bennett, D A, Jukema, J W, Paus, T, Wardlaw, J M, Schmidt, H, Sachdev, P S, Villringer, A, Grabe, H J, Longstreth, W T, van Duijn, C M, Launer, L J, Seshadri, S, Ikram, M A & Fornage, M 2018, ' Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume ', Nature Communications, vol. 9, no. 1, pp. 3945 . https://doi.org/10.1038/s41467-018-06234-w Nature Communications, 9 Nature Communications, 9(1). Nature Publishing Group UK Vojinovic, D, Adams, H H, Jian, X, Yang, Q, Smith, A V, Bis, J C, Teumer, A, Scholz, M, Armstrong, N J, Hofer, E, Saba, Y, Luciano, M, Bernard, M, Trompet, S, Yang, J, Gillespie, N A, Van Der Lee, S J, Neumann, A, Ahmad, S, Andreassen, O A, Ames, D, Amin, N, Arfanakis, K, Bastin, M E, Becker, D M, Beiser, A S, Beyer, F, Brodaty, H, Bryan, R N, Bülow, R, Dale, A M, De Jager, P L, Deary, I J, Decarli, C, Fleischman, D A, Gottesman, R F, Van Der Grond, J, Gudnason, V, Harris, T B, Homuth, G, Knopman, D S, Kwok, J B, Lewis, C E, Li, S, Loeffler, M, Lopez, O L, Maillard, P, El Marroun, H, Mather, K A, Mosley, T H, Muetzel, R L, Nauck, M, Nyquist, P A, Panizzon, M S, Pausova, Z, Psaty, B M, Rice, K, Rotter, J I, Royle, N, Satizabal, C L, Schmidt, R, Schofield, P R, Schreiner, P J, Sidney, S, Stott, D J, Thalamuthu, A, Uitterlinden, A G, Valdés Hernández, M C, Vernooij, M W, Wen, W, White, T, Witte, A V, Wittfeld, K, Wright, M J, Yanek, L R, Tiemeier, H, Kremen, W S, Bennett, D A, Jukema, J W, Paus, T, Wardlaw, J M, Schmidt, H, Sachdev, P S, Villringer, A, Grabe, H J, Longstreth, W T, Van Duijn, C M, Launer, L J, Seshadri, S, Ikram, M A & Fornage, M 2018, ' Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume ', Nature Communications, vol. 9, no. 1, 3945 . https://doi.org/10.1038/s41467-018-06234-w |
| ISSN: | 2041-1723 |
| Popis: | Publisher's version (útgefin grein) Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = −0.59, p-value = 3.14 × 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology. See Supplementary Note 2 for information on funding sources. |
| Databáze: | OpenAIRE |
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