Pharmacokinetics of tolfenamic acid in the horse
| Autor: | D. Guieu, Philippe Jaussaud, C. Bellon, D. Courtot, B. Barbier, R. Sechet, M. C. Lhopital, P. L. Toutain |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Absorption (skin) Pharmacology High-performance liquid chromatography Tolfenamic acid Pharmacokinetics Oral administration medicine Animals ortho-Aminobenzoates Horses Chromatography High Pressure Liquid Volume of distribution Blood Specimen Collection Chromatography Dose-Response Relationship Drug Chemistry Anti-Inflammatory Agents Non-Steroidal Reproducibility of Results Horse General Medicine Plasma levels Injections Intravenous Female Half-Life medicine.drug |
| Zdroj: | Equine Veterinary Journal. 24:69-72 |
| ISSN: | 2042-3306 0425-1644 |
| DOI: | 10.1111/j.2042-3306.1992.tb04778.x |
| Popis: | The pharmacokinetics of tolfenamic acid were studied in five ponies after an intravenous (iv) administration (2 mg/kg bodyweight [bwt]) and in four horses after an oral administration (30 mg/kg bwt) of tolfenamic acid. The plasma levels were determined by high pressure liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). For the iv administration, a three-compartment model was used to represent the plasma concentration-time curve of the drug. The elimination half-life of the compound was 6.1 +/- 1.5 h, the total body clearance was 72.4 +/- 16.7 ml/kg bwt/h and the steady-state volume of distribution 0.32 +/- 0.11 litres/kg bwt. For the oral administration, absorbtion was delayed with a mean lag-time to absorption of 32 +/- 28 mins. The peak plasma concentration 11.1 +/- 0.69 micrograms/ml was observed after a highly variable delay ranging from 1.9 to 6.5 h post administration. The terminal half-life (4.2 +/- 0.48 h) was very similar to that obtained after iv administration. Tolfenamic acid could not be detected in equine plasma with the described analytical methods more than 48 h after drug administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text